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Table 3 Differences in the courses of tacrolimus therapy between patients of the high dose group and low dose group

From: The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients

  Low dosea High dosea p
  n = 26 n = 21
Period required for reaching the target trough level (>10 ng/mL) of tacrolimus (day) 5 (2–13) 7 (3–17) b 0.011b
Patients who attained the target trough level (>10 ng/mL) within 7 days 23 (88%) 13 (62%) 0.043
The initial trough concentration/starting dose of tacrolimus (ng/mL/mg) 1.35 (0.50-3.60) 0.78 (0.30-1.30) <0.0001
Efficacy    
Remission 18 (70%) 12(57%) NS
Response 4 (15%) 7 (33%)  
No response 4 (15%) 2 (10%)  
Period required for reaching remission (day) 14 (5–26) 17.5 (13–27) 0.0055
Adverse events    
Required for discontinuation and reduce 6 (23%) 2 (10%) 0.27
  1. aPatients were divided into two groups by the maximum dose (<0.2 mg/kg or ≥ 0.2 mg/kg).
  2. bTwo patients of the high dose group could not achieve the trough concentration of 10 ng/mL. The analysis was performed excluding these two patients.