Table 1 Characteristics of study population
Total | 47 |
|---|---|
Age, years, median (range) | |
at onset | 30 (11–67) |
at initiation of tacrolimus | 40 (12–70) |
Disease duration, months, median (range) | 43.6 (0.74-336) |
Gender | |
Male | 24 (51%) |
Female | 23 (49%) |
Disease severity | |
Moderate | 34 (72%) |
Severe | 13 (28%) |
Extent of disease | |
Pancolitis | 34 (72%) |
Left-side colitis | 13 (28%) |
Concomitant therapy | |
5-ASA | 42 (89%) |
Corticosteroid use | 42 (89%) |
Immunomodulator use | 13 (28%) |
SNPs analysis | |
CYP3A5 (*1*1/*1*3/*3*3) | 1/12/24 |
ABCB1 exon26 (CC/CT/TT) | 15/14/8 |