Nausea, vomiting and loss of appetite were regarded as upper gastrointestinal (GI) symptoms, whereas constipation, diarrhea and fecal incontinence were regarded as lower GI symptoms. Unintentional weight loss was added to the total GI score. Medications with n < 10 were excluded. Data shown are medians and p < 0.05 was regarded as statistically significant. aused against neuropathic pain, *p <0.05, **p <0.01.