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Table 3 Univariate cox regression model of baseline characteristics and 6-month mortality in hepatocellular carcinoma (HCC) patients

From: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

Variable

Parameter estimate

SE of estimate

Risk ratio (95%CI)

Pvalue

Demographics

    

 Age (yrs)

0.011

0.016

1.011(0.981-1.043)

0.465

 Gender (F/M)

0.532

0.392

1.702(0.790-3.668)

0.174

 Varices (−/+)

1.490

0.381

4.438(2.101-9.373)

<0.001*

 Variceal rupture (−/+)

1.496

0.493

4.463(1.697-11.739)

0.002*

 IL-6 (pg/mL)

0.015

0.007

1.015(1.002-1.028)

0.024*

 IL-27 (pg/mL)

0.000

0.000

1.000(0.999-1.000)

0.204

 TNF-α (pg/mL)

−0.001

0.001

0.999(0.996-1.002)

0.401

 VEGF (pg/mL)

0.034

0.013

1.034(1.009-1.060)

0.007*

 AST (IU/L)

0.008

0.003

1.008(1.003-1.013)

0.003*

 ALT (IU/L)

0.002

0.002

1.002(0.998-1.007)

0.337

 Albumin (g/dL)

−2.413

0.444

0.090(0.038-0.214)

<0.001*

 Bilirubin (mg/dL)

0.455

0.132

1.576(1.216-2.042)

0.001*

 Cr (mg/dL)

−0.014

0.132

0.986(0.761-1.278

0.914

 INR

5.763

1.359

318.386(22.17-4572.329)

<0.001*

 Platelet (103/uL)

0.001

0.002

1.001(0.997-1.006)

0.576

 AFP (ng/mL)

0.000

0.000

1.000(1.000-1.000)

0.001*

 Cirrhosis (−/+)

1.131

0.422

3.10(1.357-7.083)

0.007*

 BCLC staging

2.394

0.411

10.958(4.897-24.522)

<0.001*

  1. (N = 147) *p < 0.05 defined as statistically significant.