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Table 3 Univariate cox regression model of baseline characteristics and 6-month mortality in hepatocellular carcinoma (HCC) patients

From: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

Variable Parameter estimate SE of estimate Risk ratio (95%CI) Pvalue
Demographics     
Age (yrs) 0.011 0.016 1.011(0.981-1.043) 0.465
Gender (F/M) 0.532 0.392 1.702(0.790-3.668) 0.174
Varices (−/+) 1.490 0.381 4.438(2.101-9.373) <0.001*
Variceal rupture (−/+) 1.496 0.493 4.463(1.697-11.739) 0.002*
IL-6 (pg/mL) 0.015 0.007 1.015(1.002-1.028) 0.024*
IL-27 (pg/mL) 0.000 0.000 1.000(0.999-1.000) 0.204
TNF-α (pg/mL) −0.001 0.001 0.999(0.996-1.002) 0.401
VEGF (pg/mL) 0.034 0.013 1.034(1.009-1.060) 0.007*
AST (IU/L) 0.008 0.003 1.008(1.003-1.013) 0.003*
ALT (IU/L) 0.002 0.002 1.002(0.998-1.007) 0.337
Albumin (g/dL) −2.413 0.444 0.090(0.038-0.214) <0.001*
Bilirubin (mg/dL) 0.455 0.132 1.576(1.216-2.042) 0.001*
Cr (mg/dL) −0.014 0.132 0.986(0.761-1.278 0.914
INR 5.763 1.359 318.386(22.17-4572.329) <0.001*
Platelet (103/uL) 0.001 0.002 1.001(0.997-1.006) 0.576
AFP (ng/mL) 0.000 0.000 1.000(1.000-1.000) 0.001*
Cirrhosis (−/+) 1.131 0.422 3.10(1.357-7.083) 0.007*
BCLC staging 2.394 0.411 10.958(4.897-24.522) <0.001*
  1. (N = 147) *p < 0.05 defined as statistically significant.