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Table 1 Baseline characteristics of healthy and chronic hepatitis (CH) and hepatocellular carcinoma (HCC) patients (N = 303)

From: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

Demographics

Non-HCC group (n = 156)

HCC group (n = 147)

 

Healthy group (n = 54)

CH group (n = 102)

HCC-NBNC (n = 13)

HCC-HBV (n = 70)

HCC-HCV (n = 64)

 Age (yrs) (range)

42.87 ± 13.35 (19–68)

50.20 ± 14.53 (19–78)

70.38 ± 8.85 (57–85)

60.00 ± 11.91 (30–86)

69.36 ± 9.71 (47–86)

 Sex (Male) (%)

33 (61.10%)

61 (59.8%)

9 (69.20%)

56 (80.00%)

37 (57.80%)

 Cirrhosis

0

13 (12.7%)

9 (69.20%)

47 (67.10%)

44 (68.80%)

 Varices/Variceal bleeding (%)

0/0

3/0

6/1

33/11

27/13

 BCLC system (Early/Intermediated/Advanced/Terminal Stage)

−/−/−/−

−/−/−/−

0/3/7/3

14/10/24/22

13/19/17/15

Biochemical values

     

 Albumin (g/dL)

4.44 ± 0.37 (3.5-5.0)

4.22 ± 0.51 (2.30-5.10)

3.32 ± 0.56 (2.40-4.50)

3.33 ± 0.73 (2.00-4.90)

3.26 ± 0.63 (2.00-4.80)

 Bilirubin (mg/dL)

0.80 ± 0.23 (0.25-1.30)

1.04 ± 0.50 (0.42-4.11)

3.42 ± 5.58 (0.44-19.84)

2.77 ± 3.42 (0.38-16.47)

1.97 ± 2.52 (0.47-14.67)

 Creatinine (mg/dL)

0.83 ± 0.20 (0.49-1.51)

0.86 ± 0.31 (0.43-2.62)

1.47 ± 0.86 (0.61-3.43)

1.10 ± 0.99 (0.42-6.95)

1.50 ± 1.60 (0.47-10.66)

 AST (IU/L)

21.86 ± 6.28 (14–51)

66.58 ± 66.16 (12–463)

121.10 ± 162.74 (29.00-578.00)

166.88 ± 428.01 (23.00-3410.00)

106.51 ± 106.86 (25.00-488.00)

 ALT (IU/L)

20.93 ± 7.16 (10–40)

86.07 ± 137.34 (13–1330)

48.38 ± 28.49 (5.00-103.00)

73.11 ± 105.62 (16.00-633.00)

72.14 ± 60.97 (10.00-366.00)

 INR

0.96 ± 0.06 (0.86-1.18)

1.02 ± 0.08 (0.87-1.42)

1.25 ± 0.41 (0.85-2.21)

1.27 ± 0.46 (0.89-4.50)

1.15 ± 0.22 (0.86-2.20)

 Platelet (103/uL)

245.46 ± 57.22 (138–351)

179.01 ± 58.24 (44–378)

163.62 ± 66.73 (22.00-265.00)

172.93 ± 91.03 (21.00-451.00)

124.50 ± 59.86 (18.00-323.0)

 AFP (ng/mL)

2.78 ± 1.45 (1.0-8.02)

21.92 ± 79.29 (0.99-611.11)

15421.25 ± 23754.14 (2.55-54001.0)

11119.34 ± 20318.09 (2.05-54001.00)

5817.04 ± 15840.43 (1.33-54001.0)

Virologic values

     

 HBeAg (+) (%)

0

9 (9/28 = 32.14%)

0

7 (10%)

0