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Table 1 Baseline characteristics of healthy and chronic hepatitis (CH) and hepatocellular carcinoma (HCC) patients (N = 303)

From: IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

Demographics Non-HCC group (n = 156) HCC group (n = 147)
  Healthy group (n = 54) CH group (n = 102) HCC-NBNC (n = 13) HCC-HBV (n = 70) HCC-HCV (n = 64)
Age (yrs) (range) 42.87 ± 13.35 (19–68) 50.20 ± 14.53 (19–78) 70.38 ± 8.85 (57–85) 60.00 ± 11.91 (30–86) 69.36 ± 9.71 (47–86)
Sex (Male) (%) 33 (61.10%) 61 (59.8%) 9 (69.20%) 56 (80.00%) 37 (57.80%)
Cirrhosis 0 13 (12.7%) 9 (69.20%) 47 (67.10%) 44 (68.80%)
Varices/Variceal bleeding (%) 0/0 3/0 6/1 33/11 27/13
BCLC system (Early/Intermediated/Advanced/Terminal Stage) −/−/−/− −/−/−/− 0/3/7/3 14/10/24/22 13/19/17/15
Biochemical values      
Albumin (g/dL) 4.44 ± 0.37 (3.5-5.0) 4.22 ± 0.51 (2.30-5.10) 3.32 ± 0.56 (2.40-4.50) 3.33 ± 0.73 (2.00-4.90) 3.26 ± 0.63 (2.00-4.80)
Bilirubin (mg/dL) 0.80 ± 0.23 (0.25-1.30) 1.04 ± 0.50 (0.42-4.11) 3.42 ± 5.58 (0.44-19.84) 2.77 ± 3.42 (0.38-16.47) 1.97 ± 2.52 (0.47-14.67)
Creatinine (mg/dL) 0.83 ± 0.20 (0.49-1.51) 0.86 ± 0.31 (0.43-2.62) 1.47 ± 0.86 (0.61-3.43) 1.10 ± 0.99 (0.42-6.95) 1.50 ± 1.60 (0.47-10.66)
AST (IU/L) 21.86 ± 6.28 (14–51) 66.58 ± 66.16 (12–463) 121.10 ± 162.74 (29.00-578.00) 166.88 ± 428.01 (23.00-3410.00) 106.51 ± 106.86 (25.00-488.00)
ALT (IU/L) 20.93 ± 7.16 (10–40) 86.07 ± 137.34 (13–1330) 48.38 ± 28.49 (5.00-103.00) 73.11 ± 105.62 (16.00-633.00) 72.14 ± 60.97 (10.00-366.00)
INR 0.96 ± 0.06 (0.86-1.18) 1.02 ± 0.08 (0.87-1.42) 1.25 ± 0.41 (0.85-2.21) 1.27 ± 0.46 (0.89-4.50) 1.15 ± 0.22 (0.86-2.20)
Platelet (103/uL) 245.46 ± 57.22 (138–351) 179.01 ± 58.24 (44–378) 163.62 ± 66.73 (22.00-265.00) 172.93 ± 91.03 (21.00-451.00) 124.50 ± 59.86 (18.00-323.0)
AFP (ng/mL) 2.78 ± 1.45 (1.0-8.02) 21.92 ± 79.29 (0.99-611.11) 15421.25 ± 23754.14 (2.55-54001.0) 11119.34 ± 20318.09 (2.05-54001.00) 5817.04 ± 15840.43 (1.33-54001.0)
Virologic values      
HBeAg (+) (%) 0 9 (9/28 = 32.14%) 0 7 (10%) 0