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Table 1 Kinetic parameters of Na-glutamine co-transport in villus cell BBMV

From: Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation

 

V max (nmol/mg protein•6 sec)

K m (mM)

Control

3.4 ± 0.1

24 ± 1.5

Inflamed

1.7 ± 0.03*

27.1 ± 1.1

Inflamed + ketotifen

3.2 ± 0.1*

23.7 ± 1.9

  1. In villus cells, the maximal rate of uptake (V max ) of Na-glutamine co-transport which was significantly diminished in chronically inflamed intestine was reversed by ketotifen treatment (n = 3, *p < 0.01).