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Table 1 Kinetic parameters of Na-glutamine co-transport in villus cell BBMV

From: Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation

  V max (nmol/mg protein•6 sec) K m (mM)
Control 3.4 ± 0.1 24 ± 1.5
Inflamed 1.7 ± 0.03* 27.1 ± 1.1
Inflamed + ketotifen 3.2 ± 0.1* 23.7 ± 1.9
  1. In villus cells, the maximal rate of uptake (V max ) of Na-glutamine co-transport which was significantly diminished in chronically inflamed intestine was reversed by ketotifen treatment (n = 3, *p < 0.01).