Table 3 Characteristics of mice in 10 and 48 week model
10 W model | 48 W model | |||||||
|---|---|---|---|---|---|---|---|---|
iNOS+/+ | iNOS−/− | iNOS+/+ | iNOS−/− | iNOS+/+ | iNOS−/− | iNOS+/+ | iNOS−/− | |
BD | BD | HFD | HFD | BD | BD | HFD | HFD | |
Number of animals | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
Liver weight (g) | 1.25 | 1.12 | 3.11* | 2.19* | 1.22 | 1.45 | 5.92 | 5.38 |
±0.07 | ±0.05 | ±0.18 | ±0.32 | ±0.24 | ±0.11 | ±0.61 | ±0.38 | |
Visceral fat weight (g/100 g BW) | 2.24 | 1.98 | 5.10 | 5.26 | 2.60 | 2.77 | 3.52 | 3.49 |
±0.15 | ±0.17 | ±0.32 | ±0.50 | ±1.18 | ±0.40 | ±0.04 | ±0.52 | |
Subcutaneous fat weight (g/100 g BW) | 0.64 | 0.74 | 4.22 | 3.81 | 1.17 | 0.91 | 4.65 | 4.91 |
±0.11 | ±0.12 | ±0.20 | ±0.37 | ±0.53 | ±0.20 | ±0.23 | ±0.66 | |
Mesenterial fat weight (g/100 g BW) | 0.36 | 0.57 | 3.02 | 3.09 | 1.10 | 0.56 | 1.39 | 1.54 |
±0.03 | ±0.08 | ±0.19 | ±0.14 | ±0.91 | ±0.04 | ±0.07 | ±0.02 | |
Serum cholesterol (mg/dL) | 86.4 | 82.6 | 167.7 | 133.3 | 88.3 | 67.7 | 230.6 | 283.7 |
±3.6 | ±5.7 | ±6.5 | ±16.6 | ±9.7 | ±4.6 | ±24.0 | ±10.4 | |
Serum TG (mg/dL) | 30.1 | 23.8 | 40.1 | 35.0 | 26.8 | 26.4 | 16.5 | 17.5 |
±3.1 | ±5.0 | ±4.5 | ±1.9 | ±3.1 | ±1.5 | ±0.4 | ±2.6 | |
Serum VLDL-TG (pg/mL) | 12.7 | 11.7 | 16.4 | 14.7 | 11.6 | 14.6 | 3.5 | 4.0 |
±4.2 | ±1.8 | ±2.4 | ±1.2 | ±1.3 | ±1.6 | ±0.1 | ±0.6 | |
Serum adiponectin (μg/mL) | 15.0 | 15.1 | 13.3 | 13.2 | 11.0 | 10.7 | 6.9* | 8.5* |
±1.4 | ±1.3 | ±0.6 | ±0.7 | ±0.7 | ±0.3 | ±0.4 | ±0.1 | |
Serum leptin (ng/mL) | 2.6 | 1.4 | 29.8 | 27.7 | 3.1 | 3.2 | 60.9* | 130.7* |
±0.5 | ±0.4 | ±1.0 | ±1.1 | ±0.6 | ±0.5 | ±12.1 | ±27.4 | |
Serum NEFA (mEq/L) | 1.0 | 0.9 | 1.5 | 1.6 | 0.9 | 1.3 | 1.7* | 2.6* |
±0.1 | ±0.1 | ±0.1 | ±0.1 | ±0.2 | ±0.2 | ±0.1 | ±0.2 | |
Liver NEFA contents (μEq/g) | 13.9 | 18.3 | 12.4 | 12.6 | 10.3 | 8.4 | 10.7 | 17.6* |
±2.5 | ±6.0 | ±1.4 | ±1.4 | ±1.1 | ±0.8 | ±1.6 | ±2.7 | |