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Table 7 Urinary histamine (UH) and methylhistamine (UMH) excretion in relation to IgE- and non-IgE induced types of gastrointestinally mediated allergy (GMA) compared to the control group

From: Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet

UH excretion Unrestricted diet Hypoallergenic potato-rice diet Statistical significance vs control group unrestricted/hypoallergenic diet
IgE GMA 1.5 (0.9–2.6) 1.1 (0.8–2.2) P < 0.0001/n.s.
Non-IgE GMA 1.4 (1.0–3.2) 1.46 (0.7–1.9) P < 0.0001/n.s.
Control group 0.9 (0.4–1.3) 1.1 (0.6–1.6)  
UMH excretion    
IgE GMA 7.1 (5.9–11.2) 5.8 (3.9–9.7) P < 0.0001/p < 0.0001
Non-IgE GMA 8.0 (4.8–11.3) 5.5 (3.1–8.2) P = 0.003/p = 0.002
Control group 4.6 (3.2–5.8) 3.8 (2.3–5.1)  
  1. UH and UMH excretion rates (median, 25–75th percentile; μg/mmol creatinine x m2 BSA) were separately analysed for the IgE- and non-IgE induced types of GMA.
  2. Statistical significance between GMA groups and controls is given in the table.
  3. In addition, there were no statistical significances for UH in the IgE- and non-IgE GMA group when comparing unrestricted diet versus hypoallergenic diet types (p = 0.09 and p = 0.27), while UMH in the IgE- and non-IgE GMA group revealed statistical significances (p = 0.04 and p = 0.002) between both diet types.