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Table 3 List of individual symptoms, causative allergens, serum IgE and identified allergy types in each patient of the study group with gastrointestinally mediated allergy (GMA)

From: Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet

Pat. no. Main symptoms & allergen(ssensitivity) Atopy status & serum-IgE Type of allergy
1 Diarrhoea, flush, pruritus - 76 Type I (systemic IgE)
  Soy flour, egg    
2 Abdominal pain, loose stools + 210 Type I (systemic IgE)
  Wheat, nuts    
3 Vomiting, diarrhoea + 112 Type I (systemic IgE)
  Egg, wheat, soy    
4 Abdominal pain, urticaria - 21 Type I (local IgE)
  Fish (salmon)    
5 Diarrhoea, abdominal pain + 65 Type I (systemic IgE)
  Dyspepsia, vomiting    
  Hazelnut, tree pollens    
6 Diarrhoea - 89 Type I (systemic IgE)
  Wheat, maize, barley    
7 Vomiting, loose stools + 112 Type I (systemic IgE)
  Right lower quadrant pain    
  Rice, peach    
8 Profuse watery diarrhoea - 398 Type I (systemic IgE)
  Milk, soy, fish    
9 Diarrhoea, bloating, tachy- + 34 Type III (immune com-
  Cardia    Plexes present) or
  Pork, beef, soy    Type IV (?)
10 Pruritus, Rhinitis, tachycardia - 54 Type I (systemic IgE)
  Bloating, diarrhoea    
  Nuts, milk    
11 Colitis, diarrhoea, arthralgia - 66 Type I (systemic IgE)
  Oral allergy syndrome, rhinitis    
  Celery, carrot, tree & grass pollen    
12 Bloody diarrhoea, hypotension, - 6 Type I (local IgE)
  And/or abdominal pain, bloating    Type III (IMMUNE
  rice, soy    Complexes)
13 Fever, diarrhoea, hypotension + 722 Type I (systemic IgE)
14 Diarrhoea, vomiting, abdominal - 6 Type IV (cellular hyper-
  Pain    Sensitivity
  cereals (rye, wheat)    
15 Bloating, diarrhoea, eosinophilia + 130 Type I (systemic Ige)
  Milk, egg    
16 Atopic eczema, diarrhoea, colitis + 76 Type I (local IgE)
  Abdominal pain    Type IV (cellular hyper-
  Nuts, tree pollen    Sensitivity ?)
17 Rhinitis, vomiting, diarrhoea + 111 Type I (local IgE)
  Nuts, egg    
18 Diarrhoea, bloating + 28 Type I (local IgE)
  Wheat, milk    
19 Eosinophilia, bloating, diarrhoea + 289 Type I (systemic IgE)
20 Gastrointestinal bleeding, colitis + 80 Type I (systemic IgE)
  Wheat, hazelnut    
21 Chronic diarrhea, bloating, pain - 12 Type IV
  Pork, beef    
22 Weight loss, diarrhea, pain - 43 Type III (immune
  soy    Complexes)
23 Loose stools, abdominal pain + 78 Type I (local IgE)
  Rice, egg    
24 Diarrhea, anaphylaxis + 312 Type I (systemic IgE)
  Milk, egg    
25 Weight loss, malabsorption - 34 Type I (local IgE)
  Milk, pork, wheat    
26 Tachycardia, abdominal pain - 7 Type I (local IgE)
27 Colitis, abdominal pain, pruritus + 92 Type I (local IgE)
  nuts, apple, tree pollen    
28 Chronic diarrhea - 8 Type IV
29 Gastroesophageal reflux + 28 Type I (local IgE)
  Eosinophilia, intermittent diarrhea    
  milk, beef, tree pollen    
30 Anaphylaxis, urticaria + 467 Type I (systemic IgE)
  Abdominal colics    
  Egg, milk    
31 Diarrhoea, bloating + 28 Type I (local IgE)
  Wheat, milk    
32 Microscopic colitis, flush - 32 Type IV
  Maize, rye    
33 Chronic diarrhea, bloating + 77 Type I (local IgE)
  Abdominal pain, rhinitis    
  Milk, house dust mite, grass pollen    
34 Epigastric and abdominal pain + 420 Type I (systemic Ige)
  Tachycardia, rhinitis, asthma bronchiale    
  Nuts, wheat, rye, oat    
35 Microscopic enteritis and colitis - 22 Type I (local IgE)
  Malabsorption, pruritus    
  Egg, wheat, pork    
36 Eosinophilic enteritis, ascites - 71 Type I (local IgE)
  Abdominal pain, loose stools    
  Maize, rice, fruits    
37 Allergic rhinoconjunctivitis, + 412 Type I (systemic IgE)
  Epigastric pain, pruritus    
  Pollen, spice, celery    
38 Chronic diarrhea, nausea + 123 Type I (systemic IgE)
  Soy, pork, rye, pollen    and type III (immune complexes)
39 Eosinophilic esophagitis + 24 Type I (local IgE) and
  Atopic dermatitis    Type IV
  Egg, milk, pollen    
40 Vomiting, flatulence, - 8 Type IV
  Wheat, rye, soy bean, milk    
41 Gastric & duodenal ulcer - 91 Type I (local IgE)
  Gastrointestinal bleeding    
  Soy flour, nuts, celery    
42 Weight loss, malabsorption + 217 Type I (systemic IgE)
  Allergic rhinoconjunctivitis    
  Apple, nuts, latex    
43 Intermittent diarrhea - 370 Type I (systemic IgE)
44 Tachycardia, restlessness - 28 Type I (systemic IgE)
  Loose stools    
  Wheat, pollen    
45 Oral allergy syndrome, + 198 Type I (systemic IgE)
  Epigastric pain    
  Nuts, fruits, pollen    
46 Watery diarrhea - 36 Type I (local IgE)
  Egg, milk    
47 Chronic diarrhea, flatulence - 30 Type IV
  soy bean, beef, chicken    
48 Urticaria, oral allergy syndrome + 42 Type I (local IgE)
  Nuts, pollen    
49 Atopic eczema, proctitis + 732 Type I (systemic IgE)
  Spice, pollen, hazelnut    
50 Gastrointestinal bleeding + 74 Type I (local IgE) and
  From enterocolitis    Type IV
51 Dysphagia, epigastric pain - 141 Type I (local IgE)
  Oral allergy syndrome    
  Fruits, hazelnut, celery    
52 Chronic diarrhea, abdominal - 65 Type I (local IgE)
  pain and edema    
  pork, maize, moulds    
53 Lymphocytic colitis + 122 Type I (systemic IgE)
  Pruritus, hypotonia    and type IV
  Banana, fruits    
54 Nausea, vomiting, flatulence + 780 Type I (systemic IgE)
55 Oral allergy syndrome, chronic - 96 Type I (local IgE)
  Wheat, rye    
56 Pruritus, weight loss, - 41 Type IV
  Wheat, rye, soy flour    
  1. Atopy status was defined as positive, when history or clinical manifestation of the patient gave evidence for seborrheic dermatitis, atopic dermatitis or eczema, asthma bronchiale and/or allergic rhino - conjunctivitis.
  2. For definition of the allergy type, the most dominant immunological signs were chosen to classify the ongoing allergic mechanisms in this population of patients with manifest gastrointestinally mediated allergy. However, some patients displayed symptoms that suggested more than one definitive type of allergy (see for example patient No. 9, 12, 16 etc.): Type I allergy (systemic IgE) was recognised when positive skin and/or antigen specific IgE levels were present in serum, type I allergy (local IgE) was diagnosed when intestinal lavage fluid contained elevated food antigen-specific levels of IgE (>0.35 U/mg protein) [11,23].
  3. Type III allergy was found in 4 patients (no. 9, 12, 22, 38) who showed formation of either IgA, IgM and/or IgE immune complexes during or after allergen application by blinded food challenge, while pre-challenge serum immune complexes were normal during potato-rice diet.
  4. Type IV allergy was diagnosed or suspected in 8 patients who showed markedly increased production of serum TNF levels during or after food challenge, while pre-challenge TNF levels were normal during potato-rice diet. Additionally, in one patient (no. 14) type IV allergy was considered because of a positive antigen-specific lymphocyte proliferation test.