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Table 3 Univariate and multivariate-adjusted logistic analysis of risk factors of T2DM in CHB patients

From: Identifying patients with chronic hepatitis B at high risk of type 2 diabetes mellitus: a cross-sectional study with pair-matched controls

Variable

DM (n = 207)

Non-DM (n = 207)

Univariate

Multivariate adjusted

OR (95% CI)

P-value

OR (95% CI)

P-value

Education

 Primary/under

106

73

1

 

1

 

 Middle/High

91

120

0.52 (0.35-0.78)

0.002

0.60 (0.37-0.99)

0.046

 College/above

10

14

0.49 (0.21-1.17)

0.108

0.54 (0.20-1.48)

0.231

Smoking

 None

132

171

1

 

1

 

 Moderate (< 10 cigarettes/d)

51

26

2.54 (1.50-4.29)

< 0.001

1.60 (0.79-3.27)

0.195

 Excessive (≥ 10 cigarettes/d)

24

10

3.11 (1.44-6.73)

0.004

2.22 (0.91-5.34)

0.080

Alcohol Consumption

 None

138

174

1

 

1

 

 Moderate (< 30/20 g/d men/women)

29

19

1.92 (1.04-3.58)

0.039

1.64 (0.74-3.60)

0.222

 Excessive (≥ 30/20 g/d men/women)

40

14

3.60 (1.88-6.89)

< 0.001

2.09 (0.90-4.83)

0.086

Hypertension

 No

165

185

1

 

1

 

 Yes

42

22

2.14 (1.23-3.74)

0.007

1.46 (0.74-2.88)

0.281

Family history of DM

 No

187

199

1

 

1

 

 Yes

20

8

2.66 (1.14-6.19)

0.023

3.85 (1.43-10.39)

0.008

Family history of CHB

 No

175

192

1

 

1

 

 Yes

32

15

2.34 (1.23-4.47)

0.010

1.45 (0.70-2.98)

0.314

Duration of CHB (year)

 <5

97

158

1

 

1

 

 5-9.9

41

22

3.04 (1.71-5.40)

< 0.001

4.32 (2.21-8.44)

< 0.001

 10-14.9

26

14

3.03 (1.51-6.07)

0.002

2.13 (0.97-4.69)

0.061

 ≥15

43

13

5.39 (2.76-10.53)

< 0.001

5.80 (2.72-12.37)

< 0.001

GGT (U/L)

 <50

31

58

1

 

1

 

 50-199

96

106

1.69 (1.01-2.84)

0.045

1.54 (0.83-2.87)

0.174

 ≥200

80

43

3.48 (1.96-6.17)

< 0.001

3.79 (1.89-7.59)

< 0.001

HBeAg positive

 No

112

141

1

 

1

 

 Yes

95

66

1.81 (1.21-2.70)

0.004

1.33 (0.80-2.22)

0.275

HBV DNA (copies/mL)

 < 103

38

68

1

 

1

 

 103-9.9*105

58

62

1.50 (0.89-2.55)

0.130

1.27 (0.66-2.43)

0.468

 ≥ 106

111

77

2.84 (1.73-4.66)

< 0.001

1.94 (1.05-3.58)

0.033

High TG (≥ 1.7 mmol/L)

 No

144

181

1

 

1

 

 Yes

63

26

3.05 (1.84-5.05)

< 0.001

2.12 (1.15-3.90)

0.016

Low HDL (< 1.0 mmol/L)

 No

138

153

1

   

 Yes

69

54

1.42 (0.93-2.16)

0.107

  

Steatosis

 No

179

197

1

   

 Non-alcoholic

10

6

1.83 (0.65-5.15)

0.249

1.28 (0.35-4.78)

0.708

 Alcoholic

18

4

4.95 (1.65-14.91)

0.004

5.24 (1.50-18,29)

0.009

Cirrhosis

 No

156

173

1

 

1

 

 Yes

51

34

1.66 (1.02-2.70)

0.040

2.00 (1.11-3.61)

0.020

HCC

 No

195

200

1

   

 Yes

12

7

1.76 (0.68-4.56)

0.246