Table 1 Comparison of characteristics between free perforation group and non-perforated group in patients with Crohn’s disease
Patients with free perforation (n = 88) | Patients without free perforation (n = 1258) | P-value | |
|---|---|---|---|
Gender (female) | 22 (25.0) | 380 (29.4) | 0.355 |
Age at diagnosis with CD (years) | 31.8 ± 13.0 | 27.5 ± 12.1 | 0.004 |
Age at diagnosis ≥30 yr (%) | 39 (44.3) | 370 (29.4) | 0.003 |
Time from the first symptom to diagnosis (months)* | 5.1 (0–276.6) | 3.5 (0–412.4) | 0.074 |
Smoking history | 15 (17.0) | 189 (15.1) | 0.640 |
Family history of IBD | 1 (1.1) | 31 (2.5) | 0.461 |
CDAI at diagnosis with CD* | 161 (30–450) | 175 (3–585) | 0.658 |
Disease Location at diagnosis with CD | |||
L1 (Terminal ileum) ± L4 | 25 (28.4) | 251 (19.4) | 0.032 |
L2 (Colon) ± L4 | 6 (6.8) | 147 (11.4) | 0.176 |
L3 (Ileocolon) ± L4 | 55 (62.5) | 852 (67.7) | 0.482 |
Disease behavior at diagnosis with CD | |||
Inflammatory (B1) | 36 (40.9) | 1060 (84.3) | <0.001 |
Stricturing (B2) | 6 (6.8) | 123 (9.5) | 0.350 |
Penetrating (B3) | 46 (52.3) | 75 (5.8) | <0.001 |
Intestinal complications during whole disease period | |||
Bowel stricture | 36 (40.9) | 318 (25.7) | 0.001 |
Perianal fistula | 26 (29.5) | 471 (37.5) | 0.138 |
Other fistula | 20 (22.7) | 184 (14.7) | 0.040 |
Intra-abdominal Abscess | 21 (23.9) | 148 (11.8) | 0.001 |
Number of CD related hospitalization | 4.9 ± 7.2 | 2.9 ± 4.4 | 0.020 |
Mortality | 4 (4.5) | 8 (0.6) | <0.001 |