Figure 2

Effects of fluvastatin (Flu) on NFκB p65 nuclear translocation, mRNA expression levels of pro-inflammatory genes in HepG2 cells and primary rat hepatocytes (PRHs). (A) Pre-treatment with Flu for 2 hr reduced the NFκB p65 nuclear translocation in PA-treated HepG2 cells and PRHs at 6 hr after treatment. ^*p < 0.05 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. PA treatment (n = 3). (B) Flu treatment inhibited the mRNA expressions of ICAM-1, IL-6 and TNF-α of PA-treated HepG2 cells while there were no significant differences in the expressions of ICAM-1, IL-6 and TNF-α between the control group and the group treated with Fluvastatin alone. ^**p < 0.01 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. PA treatment (n = 3). (C) Flu treatment decreased the mRNA expressions of ICAM-1, IL-6 and TNF-α of PA-treated PRHs, but no significant differences in the expressions of these markers between the control group and the group treated with Fluvastatin alone were noted. ^**p < 0.01 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. PA treatment (n = 3).