Figure 1

Effects of fluvastatin (Flu) on cell viability, ROS production and NADPH oxidase subunit gp91^phoxexpression in HepG2 cells and primary rat hepatocytes (PRHs). (A) Effects of Flu on cell viability of HepG2 cells and PRHs at 24 hr after treatment (n = 3). (B) Flu significantly reduced the reactive oxygen species (ROS) production of PA-treated HepG2 cells and PRHs at 6 hr after treatments. ^*p < 0.05 and ^**p < 0.01 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. PA treatment (n = 3). (C) Flu significantly attenuated the ROS production of PA-treated HepG2 and PRHs at 12 hr after treatments. ^*p < 0.05 and ^**p < 0.01 vs. control; ^#p < 0.05 and ^##p < 0.01 vs. PA treatment (n = 3). (D) Flu significantly decreased the expression of NADPH oxidase gp91^phox in PA-treated HepG2 cells (left panel) and PRHs (right panel). ^**p < 0.01 vs. control; ^#p < 0.05 vs. PA treatment (n = 3).