Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse

Kang, Won Kyung; Lee, Jin Kwon; Oh, Seong Taek; Lee, Sung Hak; Jung, Chan Kwon

doi:10.1186/s12876-015-0227-0

BMC Gastroenterology

Table 4 Characteristics of studies that evaluated the association between the high expression of miR-21 and recurrence-free survival or overall survival in colorectal cancer

From: Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse

First author (reference)	Year	Origin	No. of cases	AJCC stage	Recurrence-free survival		Overall survival		Cut-off value	Statistic analysis	Detection method
First author (reference)	Year	Origin	No. of cases	AJCC stage	HR	95% CI	HR	95% CI	Cut-off value	Statistic analysis	Detection method
Schetter [13]	2008	USA	^aCC 71	I-IV	NA	NA	2.7	1.3-5.5	Third tertile	Multivariate	RT-PCR
		China	^aCC 103	I-IV	NA	NA	2.4	1.4-4.1	Dichotomize	Multivariate	Microarray
Shibuya [18]	2010	Japan	CRC 156	I-IV	0.396	0.186-0.897	0.513	0.280-0.956	Mean	Multivariate	RT-PCR
Nielsen [19]	2011	Denmark	CC 129	II	1.28	1.06-1.55	1.17	1.02-1.34	Dichotomize	Multivariate	ISH
			RC 67	II	0.85	0.73–1.01	0.97	0.83-1.13	Dichotomize	Multivariate	ISH
Kjaer-Frifeldt [20]	2012	Denmark	CC 764	II	1.41	1.19-1.67	1.05	0.94-1.18	Mean log	Multivariate	ISH
Zhang [29]	2013	China	CC 138	II	1.98	0.95-4.15	NA	NA	Dichotomize	Univariate	RT-PCR
			CC 137	II	1.88	0.95-3.75	NA	NA	Dichotomize	Univariate	RT-PCR
			CC 255	II	1.79	1.22-2.62	NA	NA	Dichotomize	Univariate	RT-PCR
Bovell [30]	2013	USA	CRC 55	IV	NA	NA	3.25	1.37-7.72	Mean	Multivariate	RT-PCR
Toiyama [31]	2013	Japan	CRC 166	I-IV	NA	NA	0.59	0.21-1.63	3.7	Multivariate	RT-PCR
Chen [32]	2013	Taiwan	CRC 195	I-IV	NA	NA	1.655	0.992-2.762	Mean	Univariate	RT-PCR
Hansen [33]	2014	Denmark	CC 554	II	1.348	1.032-1.760	1.075	0.889-1.301	Dichotomize	Multivariate	RT-PCR
Oue [34]	2014	Japan	CC 156	I-IV	NA	NA	1.80	0.91-3.58	Third tertile	Multivariate	RT-PCR
			CC 87	II-III	NA	NA	3.13	1.20-8.17	Third tertile	Multivariate	RT-PCR
		Germany	CC 145	II	NA	NA	2.65	1.06-6.66	Third tertile	Multivariate	RT-PCR
Present study		Korea	CC 173	II-III	3.09	1.41-6.76	0.425	0.142-1.271	Dichotomize	Multivariate	ISH
			RC 104	II-III	1.32	0.62-2.85	2.046	0.557-7.513	Dichotomize	Multivariate	ISH

^aOnly including patients with typical adenocarcinoma. AJCC, American Joint Committee on Cancer; CI, confidence interval; HR, hazard ratio; NA, not available; RT-PCR, reverse-transcription PCR; ISH, in situ hybridization; CC, colon cancer; RC, rectal cancer; CRC, colorectal cancer.

Back to article page

ISSN: 1471-230X

Contact us

Submission enquiries: bmcgastroenterology@biomedcentral.com
General enquiries: ORSupport@springernature.com