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Table 3 Association of H. pylori, cagA and EPIYA-C motif number with chronic gastritis, peptic ulcer and gastric cancer

From: The EPIYA-ABCC motif pattern in CagA of Helicobacter pyloriis associated with peptic ulcer and gastric cancer in Mexican population

  H. pylori
Diagnosis Negative Positive OR CI 95%
G 182 220 1.0 -
PU 24 53 1.8c 1.0-3.0
GC 6 14 1.9 0.72-5.1
Total 212 287   
  CagA
  Negative Positive OR CI 95%
G 56 164 1.0 -
PU 14 39 0.9 0.5- 1.9
GC 3 11 1.2 0.3 – 4.6
Total 73 214   
  EPIYA motif
  ABC ABCC OR IC95%
G 130 33 1.0 -
PU 14 25 7.0a 3.3 – 15.1
GC 4 6 5.9b 1.5-22.1
Total 148 64   
  Number of EPIYA-C
  1 C* ≥2 Cϕ OR IC95%
G 130 34 1.0 -
PU 14 25 6.8a 3.2-15.6
GC 5 6 4.5c 1.3-15.9
Total 149 65   
  1. G; chronic gastritis, UP peptic ulcer, CG: gastric cancer. ap < 0.001 ; bp <0.01; cp < 0.05. * The EPIYA-ABBC was added; ϕ the EPIYA-ABBCCC was added
  2. Note: Only the most frequent EPIYA motifs were considered.