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Table 2 Univariate analysis in prediction of significant liver histology

From: HBV DNA level could predict significant liver fibrosis in HBeAg negative chronic hepatitis B patients with biopsy indication

Parameters Significant liver inflammation Significant liver fibrosis Significant liver inflammation or fibrosis
n/N Percent p- value n/N Percent p- value n/N Percent p- value
Age ≤ 40 years 3/7 42.9 0.160 4/7 57.1 0.107    
Age ≤ 42 years 4/8 50 0.039 5/8 62.5 0.032    
Age ≤ 50 years 4/11 36.4 0.155 5/11 45.5 0.181    
BMI < 23 kg/m2 4/9 44.4 0.067     5/9 55.6 0.135
BMI < 24.5 kg/m2 5/13 38.5 0.049     7/13 53.8 0.052
BMI < 25 kg/m2 5/15 33.3 0.114     8/15 53.3 0.020
TB < 0.45 mg/dL 4/8 50 0.039       
AST > 19 mg/dL 4/19 21.1 0.558       
AST > 30 mg/dL 4/8 50 0.021       
AST > 40 mg/dL 3/5 60 0.055       
AST > 50 mg/dL 1/1 100 0.227       
ALT > 30 mg/dL 4/12 33.3 0.218       
ALT > 40 mg/dL 3/8 37.5 0.233       
ALP > 78 mg/dL 4/5 80 0.003     4/5 80 0.039
Absolute neutrophil count > 4,300/mm3 3/4 75 0.024       
LS values ≥ 7.0 kPa 3/10 30 0.406     5/10 50 0.221
LS values ≥ 8.5 kPa 3/5 60 0.233     5/8 62.5 0.072
LS values ≥ 9.5 kPa 3/5 60 0.055     3/5 60 0.233
LS values ≥ 11.5 kPa 2/2 100 0.043     2/2 100 0.121
HBV DNA levels > 4 log IU/mL     5/14 35.7 0.490    
HBV DNA levels > 5 log IU/mL     5/11 45.5 0.181    
HBV DNA levels > 5.5 log IU/mL     5/6 83.3 0.004    
HBV DNA levels > 6 log IU/mL     3/4 75 0.077