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Table 4 Level of significance and odds ratio’s for different variables used in a multivariate logistic regression model predicting sensitivity of a FIT at cut-off of 75 ng/ml for detection of CRC and advanced adenomas

From: Prospective cross-sectional study on faecal immunochemical tests: sex specific cut-off values to obtain equal sensitivity for colorectal cancer?

  CRC   Advanced adenoma
Univariate model Multivariate model Univariate model Multivariate model
Variable OR (95% CI) p-value OR (95% CI) p-value Variable OR (95% CI) p-value OR (95% CI) p-value
Sex (ref = female) (N = 69) 5.77 (1.33-24.95) 0.02 6.16 (1.15-32.92) 0.03 Sex (ref = female) (N = 304) 1.23 (0.75-2.00) 0.41 1.00 (0.57-1.75) 0.99
Age (continuous variable) (N = 69) 1.01 (0.94-1.08) 0.89 1.00 (0.92-1.08) 0.96 Age (continuous variable) (N = 304) 1.01 (0.98-1.03) 0.55 1.00 (0.98-1.03) 0.75
Location (ref = right-sided) (N = 68) 4.30 (1.07-17.35) 0.04 4.83 (0.95-24.8) 0.05 Location (ref = right-sdided (N = 303) 1.94 (1.26-2.98) 0.002 1.31 (0.79-2.20) 0.30
T-stage (ref = T1) (N = 55) 1.57 (0.39-6.32) 0.53 2.19 (0.44-10.80) 0.34 AA size (ref = <10 mm) (N = 285) 5.58 (2.55-12.22) <0.001 5.24 (2.32-11.83) <0.001
Presence of AA (ref = none) (N = 69) 0.83 (0.09-7.54) 0.87 1.38 (0.09-20.52) 0.81 Number of AA (ref = 1) (N = 300) 4.82 (2.63-8.85) <0.001 4.27 (2.10-8.70) <0.001
  1. FIT = faecal immunochemical test; CRC = colorectal cancer; AA = advanced adenoma; OR = odds ratio; CI = confidence interval.