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Table 3 Comparison of sensitivity and specificity of a FIT for detection of CRC and advanced adenomas in males and females at different cut-off values

From: Prospective cross-sectional study on faecal immunochemical tests: sex specific cut-off values to obtain equal sensitivity for colorectal cancer?

CRC Advanced adenoma
Sensitivity Sensitivity
FIT cut-off Total N = 69* Males N = 45* Females N = 24* Difference p-value FIT cut-off Total N = 304 Males N = 164 Females N = 140 Difference p-value
50 ng/ml (CI) 88.4% (78–95) 93.3% (82–99) 79.2% (58–93) 14.1% 0.12 50 ng/ml (CI) 34.9% (30–41) 36.6% (39–45) 32.9% (25–41) 3.7% 0.55
75 ng/ml (CI) 85.5% (75–93) 93.3% (82–99) 70.8% (49–87) 22.5% 0.03 75 ng/ml (CI) 30.9% (26–37) 32.9% (26–41) 28.6% (21–37) 4.3% 0.46
100 ng/ml (CI) 85.5% (75–93) 93.3% (82–99) 70.8% (49–87) 22.5% 0.03 100 ng/ml (CI) 28.6% (24–34) 31.7% (25–39) 25.0% (18–33) 6.7% 0.21
200 ng/ml (CI) 75.4% (64–85) 80.0% (65–90) 66.7% (45–84) 13.3% 0.25 200 ng/ml (CI) 21.1% (17–26) 24.4% (18–32) 17.1% (11–24) 7.3% 0.16
Specificity Specificity
FIT cut-off Total N = 2,953 # Males N = 1,312 # Females N = 1,641 # Difference p-value FIT cut-off Total N = 2,649 Males N = 1,148 Females N = 1,501 Difference p-value
50 ng/ml (CI) 89.5%(88–91) 87.3% (85–89) 91.2% (90–93) −3,9% <0,05 50 ng/ml (CI) 92.3% (91–93) 90.8% (89–92) 93.4% (92–95) −2.6% <0.05
75 ng/ml (CI) 91.5% (90–95) 90.1% (88–92) 92.6% (91–94) −2,5% <0,05 75 ng/ml (CI) 94.0% (93–95) 93.4% (92–95) 94.5% (93–96) −1.1% 0.22
100 ng/ml (CI) 92.6% (92–94) 91.2% (90–93) 93.7% (92–95) −2,5% <0,05 100 ng/ml (CI) 95.0% (94–96) 94.4% (93–96) 95.5% (94–97) −1.1% 0.24
200 ng/ml (CI) 94.8% (94–96) 93.6% (21–95) 95.8% (95–97) −2,2% <0,05 200 ng/ml (CI) 96.6% (96–97) 96.2% (95–97) 97.0% (96–98) −0.8% 0.28
  1. *This concerns the total of subjects with CRC from which the sensitivity was calculated. #This concerns the total of subjects without CRC from which the specificity was calculated. This concerns the total of subjects with advanced adenoma from which the sensitivity was calculated. This concerns the total of subjects without CRC and without advanced adenomas from which the specificity was calculated. FIT = faecal immunochemical test; CRC = colorectal cancer; CI = confidence interval.