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Table 2 Nerve fiber density and distribution in colon was identical in saline- and buserelin-treated rats

From: Structural and functional consequences of buserelin-induced enteric neuropathy in rat

  CGRP CART Gal GRP NPY NOS 5-HT Som SP VIP VAchT
M (+) ++ ++ ++ ++ + (+) + (+) +++ (+)
SM (+) + ++ ++ +++ + 0 + (+) +++ (+)
SG + ++ +++(+) +++ ++ ++ 0 + (+) +++ +
MG + +++ +++ +++ ++ +++ + + ++ ++ ++
CM (+) ++++ +(+) + ++ +++(+) 0 (+) (+) ++ (+)
LM (+) + (+) + ++ + 0 (+) (+) + +
BV (+) (+) 0 0 +++ (+) 0 + 0 (+) 0
  1. The colon mucosa (M), submucosa (SM), submucous ganglia (SG), myenteric ganglia (MG) circular (CM) and longitudinal (LM) muscle layers, and blood vessels (BV) were evaluated separately. The density and distribution of nerve fibers immunoreactive to calcitonin gene-related peptide (CGRP), cocaine- and amphetamine-related transcript (CART), galanin (Gal), gastrin-releasing peptide (GRP), neuropeptide Y (NPY), nitric oxide synthase (NOS), serotonin (5-HT), somatostatin (Som), substance P (SP), vasoactive intestinal peptide (VIP), and vesicular acetylcholine transporter (VAchT) in colon of saline- and buserelin-treated rats are shown combined as no differences in nerve fiber density and distribution were found between groups. Nerve fiber density was evaluated on a 0, (+), +, ++, +++ scale, where 0 indicates no fibers, (+) = occasional fibers, + = few fibers, ++ = moderate numbers of fibers, and +++ = numerous fibers. n = 5–11.