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Table 1 Demographic and clinical characteristics of patient cohorts profiled for expression of NALPs and other inflammasome components and targets

From: Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects

Demographic or clinical parameter (N = 45) Average ± SD or percentage
Clinical & Demographic Data
BMI 47.4 ± 10.8
Age 42.7 ± 11.9
Gender (Females) 62.2%
Triglyceride (mg/dL) 158.3 ± 96.7
AST (U/L) 27.7 ± 18.8
ALT (U/L) 36.7 ± 29.3
Glucose (mg/dL) 106.4 ± 32.2
Diabetes (Presence) 57.7%
Liver Histological Data
Non-NASH NAFLD 55.5%
NASH (Presence) 44.4%
Ballooning Degeneration (Presence) 28.8%
Mallory-Denk Bodies (Presence) 11.1%
Portal Inflammation (Presence) 66.6%
Advanced Lobular Inflammation (Score ≥ 3) 28.8%
Pericellular Fibrosis (Presence) 44.4%
Portal Fibrosis (Presence) 75.5%
Advanced Fibrosis (Score ≥ 3) 31.1%
Focal Necrosis (Presence) 31.1%
  1. Steatosis is histologically defined by the presence of ≥ 5% hepatic fat with/without lobular inflammation and with/without portal inflammation. The degree of lobular inflammation is defined by the sum of the scores for the presence of lymphoplasmacytic cells, Kupffer cell hypertrophy and neutrophil infiltration. NASH is histologically defined by the presence of steatosis along with lobular inflammation, with/without ballooning degeneration and/or Mallory-Denk bodies and/or pericellular fibrosis. Lymphoplasmacytic cells, Kupffer cell hypertrophy and neutrophil infiltration was each scored on a scale of 0–3: 0 = none, 1 = mild or few, 2 = moderate, 3 = marked or many. Portal inflammation, hepatocellular ballooning, pericellular/perisinusoidal fibrosis, and portal fibrosis were graded on a scale of 0 to 3: (0) none, (1) mild or few, (2) moderate, or (3) marked or many. Advanced fibrosis was defined by a sum of score of portal and pericellular fibrosis as being greater or equal to 3. Bridging fibrosis was scored as (0) none, (1) few bridges, or (2) many bridges. Cirrhosis was scored as (0) absent, (1) incomplete, or (2) established [22].