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Table 9 Genotype-phenotype correlations in patients with Crohn’s disease

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Parameter N Asp299gly (%) P value Chi-square test Thr399Ile (%) P value Chi-square test
AA AG GG CC CT TT   
Age of onset 83     0.48 1.45     0.59 1.05
<17 years 10 10 (100.0) -     10 (100.0) -    
17-40 63 55 (87.3.) 8 (12.7)     57 (90.5) 6 (9.5)    
>40 years 10 9 (90.0) 1 (10.0)     9 (90.0) 1 (10.0)    
Sex 83     0.35 0.87     0.17 1.92
Woman 25 24 (96.0) 1 (4.0)     25 (100.0) -    
Man 58 50 (86.2) 8 (13.8)     51 (87.9) 7 (12.1)    
Type 83     0.54 2.14     0.36 3.23
Fistulizing 35 31 (88.6) 4 (11.4)     33 (94.3) 2 (5.7)    
Non fistulizing non stenosing 24 20 (83.3) 4 (16.7)     20 (83.3) (16.7)    
Stenosing 17 16 (94.1) 1 (5.9)     16 (94.1) 1 (5.9)    
Fistulizing stenosing 7 7 (100.0) -     7 (100.0) -    
Localization 83     0.80 1.67     0.94 0.82
L1 30 26 (86.7) 4 (13.3)     27 (90.0) 3 (10.0)    
L2 20 17 (85.0) 3 (5.0)     18 (90.0) 2 (10.0)    
L3 26 24 (92.3) 2 ()     24 (92.3) 2 (7.7)    
L4 3 3 (100.0) -     3 (100.0) -    
L4 + L2 4 4 (100.0) -     4 (100.0) -    
Smoking 83     0.04 4.44     0.17 1.92
Presence 33 26 (78.8) 7 (21.2)     28 (84.8) 5 (15.2)    
Absence 50 48 (96.0) 2 (4.0)     48 (96) 2 (4.0)    
SFC 83     0.91 0.01     0.76 0.09
Presence 4 4 (100.0) -     4 (100.0) -    
Absence 79 70 (88.6) 9 (11.4)     72 (91.1) 7 (8.9)    
Appendectomy 83     0.84 0.04     0.58 0.30
Presence 12 11 (91.7) 1 (8.3)     10 (83.3) 2 (16.7)    
Absence 71 63 (88.7) 8 (11.3)     66 (93.0) 5 (7.0)    
EIM 83     0.97 0.001     0.97 0.001
Presence 42 38 (90.5) 4 (9.5)     39 (92.9) 3 (7.1)    
Absence 41 36 (87.8) 5 (12.2)     37 (95.1) 4 (4.9)    
Surgery 83     0.50 0.45     0.45 0.57
Presence 41 38 (92.7) 3 (7.3)     39 (95.1) 2 (4.9)    
Absence 42 36 (85.7) 6 (14.3)     37 (88.1) 5 (11.9)    
  1. SFC: similar familial cases; EIM: extra intestinal manifestations; N: total number; AA: wild type TLR4 Asp299gly, AG: TLR4 Asp299gly heterozygous variant, GG: TLR4 Asp299gly homozygous variant; CC: wild type TLR4 Thr399Ile, CT: TLR4 Thr399Ile heterozygous variant, TT: TLR4 Thr399Ile homozygous variant.