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Table 5 Pooled analysis of studies exploring the role of TLR4 Asp299Gly in IBD

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study Sample size Cases (Events/Total) Controls (Events/Total) Odds ratio 95% CI P value
Arnott et al. 2004 [ [31]] IBD: 480 85/960 33/378 1,016 0,667 to 1,54  
HC: 189
Franchimont et al. 2004 [ [32]] IBD: 610 131/1220 14/278 2,268 1,286 to 4,00  
HC: 139
Torok et al. 2004 [ [33]] IBD: 200 32/400 12/290 2,014 1,019 to 3,98  
HC: 145
Braat et al. 2005 [ [34]] IBD: 637 92/1274 13/274 1,563 0,861 to 2,83  
HC: 137
Gazouli et al. 2005 [ [36]] IBD: 205 25/410 6/200 2,100 0,847 to 5,20  
HC: 100
Oostenbrug et al. 2005 [ [37]] IBD: 572 74/1144 27/592 1,447 0,921 to 2,27  
HC: 296
Baumgart et al. 2007 [ [21]] (1) IBD: 262 14/524 16/404 0,666 0,321 to 1,38  
HC: 202
Baumgart et al. 2007 [ [21]] (2) IBD: 386 52/772 49/806 1,116 0,745 to 1,67  
HC: 403
Browning et al. 2007 [ [42]] IBD: 796 101/1592 44/832 1,213 0,843 to 1,74  
HC: 416
Riis et al. 2007 [ [43]] IBD: 615 85/1230 152/1236 0,529 0,401 to 0,69  
HC: 618
De Ridder et al. 2007 [ [23]] IBD: 103 15/206 20/488 1,838 0,921 to 3,66  
De Ridder et al. 2007 [ [23]] IBD: 604 96/1208 20/488 2,020 1,233 to 3,31  
HC: 244
Rigoli et al. 2008 [ [45]] IBD: 178 13/356 8/206 0,938 0,382 to 2,30  
HC: 103
Manolakis et al. 2013 [ [46]] IBD: 350 61/700 33/548 1,490 0,960 to 2,31  
HC: 274
Our study 2014 IBD:117 15/234 10/224 1,466 0,644 to 3,33  
HC:112
Total (fixed effects)   891/12230 457/7244 1,154 1,021 to 1,30 0.015
Total (random effects)   891/12230 457/7244 1,306 1,006 to 1,69