Table 5 Pooled analysis of studies exploring the role of TLR4 Asp299Gly in IBD
From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis
Study | Sample size | Cases (Events/Total) | Controls (Events/Total) | Odds ratio | 95% CI | P value |
|---|---|---|---|---|---|---|
Arnott et al. 2004 [ [31]] | IBD: 480 | 85/960 | 33/378 | 1,016 | 0,667 to 1,54 | |
HC: 189 | ||||||
Franchimont et al. 2004 [ [32]] | IBD: 610 | 131/1220 | 14/278 | 2,268 | 1,286 to 4,00 | |
HC: 139 | ||||||
Torok et al. 2004 [ [33]] | IBD: 200 | 32/400 | 12/290 | 2,014 | 1,019 to 3,98 | |
HC: 145 | ||||||
Braat et al. 2005 [ [34]] | IBD: 637 | 92/1274 | 13/274 | 1,563 | 0,861 to 2,83 | |
HC: 137 | ||||||
Gazouli et al. 2005 [ [36]] | IBD: 205 | 25/410 | 6/200 | 2,100 | 0,847 to 5,20 | |
HC: 100 | ||||||
Oostenbrug et al. 2005 [ [37]] | IBD: 572 | 74/1144 | 27/592 | 1,447 | 0,921 to 2,27 | |
HC: 296 | ||||||
Baumgart et al. 2007 [ [21]] (1) | IBD: 262 | 14/524 | 16/404 | 0,666 | 0,321 to 1,38 | |
HC: 202 | ||||||
Baumgart et al. 2007 [ [21]] (2) | IBD: 386 | 52/772 | 49/806 | 1,116 | 0,745 to 1,67 | |
HC: 403 | ||||||
Browning et al. 2007 [ [42]] | IBD: 796 | 101/1592 | 44/832 | 1,213 | 0,843 to 1,74 | |
HC: 416 | ||||||
Riis et al. 2007 [ [43]] | IBD: 615 | 85/1230 | 152/1236 | 0,529 | 0,401 to 0,69 | |
HC: 618 | ||||||
De Ridder et al. 2007 [ [23]] | IBD: 103 | 15/206 | 20/488 | 1,838 | 0,921 to 3,66 | |
De Ridder et al. 2007 [ [23]] | IBD: 604 | 96/1208 | 20/488 | 2,020 | 1,233 to 3,31 | |
HC: 244 | ||||||
Rigoli et al. 2008 [ [45]] | IBD: 178 | 13/356 | 8/206 | 0,938 | 0,382 to 2,30 | |
HC: 103 | ||||||
Manolakis et al. 2013 [ [46]] | IBD: 350 | 61/700 | 33/548 | 1,490 | 0,960 to 2,31 | |
HC: 274 | ||||||
Our study 2014 | IBD:117 | 15/234 | 10/224 | 1,466 | 0,644 to 3,33 | |
HC:112 | ||||||
Total (fixed effects) | 891/12230 | 457/7244 | 1,154 | 1,021 to 1,30 | 0.015 | |
Total (random effects) | 891/12230 | 457/7244 | 1,306 | 1,006 to 1,69 |