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Table 4 Pooled analysis of studies exploring the role of TLR4 Thr399Ile in UC

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study Sample size Cases (Events/Total) Controls (Events/Total) Odds 95% CI P value
Torok et al. 2004 [ [33]] UC: 98 22/196 12/290 2.929 1.41 to 6.06  
HC: 145
Gazouli et al. 2005 [ [36]] UC: 85 3/170 2/200 1.778 0.29 to 10.77  
HC: 100
Oostenbrug et al. 2005 [ [37]] UC: 179 24/434 19/598 1.784 0.96 to 3.30  
HC: 296
Zouiten-Mekki et al. 2009 [ [40]] UC: 30 2/60 2/160 2.724 0.37 to 19.78  
HC: 80
Browning et al. 2007 [ [42]] UC: 405 59/810 46/832 1.342 0.90 to 1.99  
HC: 416
De Ridder et al. 2007 [ [23]] UC: 257 34/514 22/488 1.500 0.86 to 2.60  
HC: 244
Rigoli et al. 2008 [ [45]] UC: 45 3/90 6/206 1.149 0.28 to 4.70  
HC:103
Manolakis et al. 2013 [ [46]] UC: 187 41/374 33/548 1.921 1.19 to 3.10  
HC: 274
Our study 2014 UC: 34 3/68 3/224 3.400 0.67 to 17.25  
HC: 112
Total (fixed effects)   191/2716 145/3546 1.695 1.35 to 2.11 0.0001
Total (random effects)   191/2716 145/3546 1.699 1.35 to 2.12