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Table 3 Pooled analysis of studies exploring the role of TLR4 Thr399Ile in CD

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study Sample size Cases (Events/Total) Controls (Events/Total) Odds ratio 95% CI P value
Torok et al. 2004 [ [33]] CD: 102 16/204 12/290 1.972 0.91 to 4.26  
HC: 145
Braat et al. 2005 [ [34]] CD: 204 30/408 19/398 1.583 0.87 to 2.86  
HC: 199
Gazouli et al. 2005 [ [36]] CD: 120 1/240 2/200 0.414 0.037 to 4.60  
HC: 100
Oostenbrug et al. 2005 [ [37]] CD: 393 69/1008 29/598 1.442 0.92 to 2.25  
HC: 296
Zouiten-Mekki et al. 2009 [ [40]] CD: 90 13/180 8/160 1.479 0.59 to 3.66  
HC: 80
Hong et al. 2007 [ [41]] CD: 182 30/364 32/376 0.966 0.57 to 1.62  
HC: 188
Browning et al. 2007 [ [42]] CD: 389 47/778 46/832 1.099 0.72 to 1.67  
HC: 416
De Ridder et al. 2007 [ [23]] CD: 450 72/900 22/488 1.842 1.12 to 3.00  
HC: 244
Rigoli et al. 2008 [ [45]] CD: 133 8/266 6/206 1.034 0.35 to 3.02  
HC:103
Azzam et al. 2012 [ [47]] CD: 46 26/92 22/100 1.397 0.72 to 2.69  
HC: 50
Manolakis et al. 2013 [ [46]] CD: 163 20/326 33/548 1.020 0.57 to 1.80  
HC: 274
Our study 2014 CD: 83 7/166 3/224 3.243 0.82 to 12.73  
HC: 112
Total (fixed effects)   339/4932 234/4420 1.345 1.12 to 1.60 0.002
Total (random effects)   339/4932 234/4420 1.336 1.11 to 1.59