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Table 10 Genotype-phenotype correlations in patients with ulcerative colitis

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Parameter

N

Asp299gly (%)

P value

Chi-square test

Thr399Ile (%)

P value

Chi-square test

AA

AG

GG

CC

CT

TT

  

Age of onset

34

   

0.35

0.89

   

0.34

2.13

<17 years

-

-

-

   

-

-

   

17-40

20

18 (90.0)

2 (10.0)

-

  

19 (95.0)

1 (5.0)

-

  

>40 years

14

10 (71.4)

4 (28.6)

-

  

13 (92.9)

-

1 (7.1)

  

Sex

34

   

0.89

0.018

   

0.36

2.06

Woman

15

13 (86.7)

2 (13.3)

-

  

14 (93.3)

1 (6.7)

-

  

Man

19

15 (78.9)

4 (21.1)

-

  

18 (94.7)

-

1 (5.3)

  

Extent of the disease

34

   

0.31

3.55

   

0.16

9.34

E1

4

2 (50.0)

2 (50.0)

-

  

3 (75.0)

-

1 (25.0)

  

E2

15

13 (86.7)

2 (13.3)

-

  

15 (100.0)

-

-

  

E3

2

2 (100.0)

-

-

  

2 (100.0)

-

-

  

E4

13

11 (84.6)

2 (15.4)

-

  

12 (92.3)

1 (7.7)

-

  

SFC

34

   

0.39

0.74

   

0.97

0.06

Presence

1

1 (100.0)

-

-

  

1 (100.0)

-

   

Absence

33

27 (81.8)

6 (18.2)

-

  

31 (93.9)

1 (3.0)

1 (3.0)

  

Smoking

34

   

0.93

0.008

   

0.20

3.17

Presence

9

7 (77.8)

2 (22.2)

-

  

8 (88.9)

-

1 (11.1)

  

Absence

25

21 (84.)

4 (16.0)

-

  

24 (96.0)

1 (4.0)

-

  

EIM

34

   

0.89

0.018

   

0.35

2.05

Presence

19

15 (78.9)

4 (21.1)

-

  

18 (94.7)

-

1 (5.3)

  

Absence

15

13 (86.7)

2 (13.3)

-

  

14 (93.3)

1 (6.7)

-

  

Surgery

34

   

0.004

8.3

   

0.08

4.97

Presence

6

2 (33.3)

4 (66.7)

-

  

5 (83.3)

1 (16.7)

-

  

Absence

28

26 (92.9)

2 (7.1)

-

  

27 (96.4)

-

1 (3.6)

  
  1. SFC: similar familial cases; EIM: extra intestinal manifestations; N: total number; AA: wild type TLR4 Asp299gly, AG: TLR4 Asp299gly heterozygous variant, GG: TLR4 Asp299gly homozygous variant; CC: wild type TLR4 Thr399Ile, CT: TLR4 Thr399Ile heterozygous variant, TT: TLR4 Thr399Ile homozygous variant.