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Table 10 Genotype-phenotype correlations in patients with ulcerative colitis

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Parameter N Asp299gly (%) P value Chi-square test Thr399Ile (%) P value Chi-square test
AA AG GG CC CT TT   
Age of onset 34     0.35 0.89     0.34 2.13
<17 years - - -     - -    
17-40 20 18 (90.0) 2 (10.0) -    19 (95.0) 1 (5.0) -   
>40 years 14 10 (71.4) 4 (28.6) -    13 (92.9) - 1 (7.1)   
Sex 34     0.89 0.018     0.36 2.06
Woman 15 13 (86.7) 2 (13.3) -    14 (93.3) 1 (6.7) -   
Man 19 15 (78.9) 4 (21.1) -    18 (94.7) - 1 (5.3)   
Extent of the disease 34     0.31 3.55     0.16 9.34
E1 4 2 (50.0) 2 (50.0) -    3 (75.0) - 1 (25.0)   
E2 15 13 (86.7) 2 (13.3) -    15 (100.0) - -   
E3 2 2 (100.0) - -    2 (100.0) - -   
E4 13 11 (84.6) 2 (15.4) -    12 (92.3) 1 (7.7) -   
SFC 34     0.39 0.74     0.97 0.06
Presence 1 1 (100.0) - -    1 (100.0) -    
Absence 33 27 (81.8) 6 (18.2) -    31 (93.9) 1 (3.0) 1 (3.0)   
Smoking 34     0.93 0.008     0.20 3.17
Presence 9 7 (77.8) 2 (22.2) -    8 (88.9) - 1 (11.1)   
Absence 25 21 (84.) 4 (16.0) -    24 (96.0) 1 (4.0) -   
EIM 34     0.89 0.018     0.35 2.05
Presence 19 15 (78.9) 4 (21.1) -    18 (94.7) - 1 (5.3)   
Absence 15 13 (86.7) 2 (13.3) -    14 (93.3) 1 (6.7) -   
Surgery 34     0.004 8.3     0.08 4.97
Presence 6 2 (33.3) 4 (66.7) -    5 (83.3) 1 (16.7) -   
Absence 28 26 (92.9) 2 (7.1) -    27 (96.4) - 1 (3.6)   
  1. SFC: similar familial cases; EIM: extra intestinal manifestations; N: total number; AA: wild type TLR4 Asp299gly, AG: TLR4 Asp299gly heterozygous variant, GG: TLR4 Asp299gly homozygous variant; CC: wild type TLR4 Thr399Ile, CT: TLR4 Thr399Ile heterozygous variant, TT: TLR4 Thr399Ile homozygous variant.