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Table 1 Pooled analysis of studies exploring the role of TLR4 Asp299Gly in CD

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study Cases (Events/Total) Controls (Events/Total) Odds ratio 95% CI P value
Arnott et al. 2004 [ [31]] 50/468 33/378 1,25 0,79 to 1,98  
Franchimont et al. 2004 [ [32]] (1) 73/668 14/278 2,31 1,28 to 4,17  
Franchimont et al. 2004 [ [32]] (2) 26/226 14/278 2,45 1,25 to 4,81  
Torok et al. 2004 [ [33]] 14/204 12/290 1,70 0,77 to 3,77  
Braat et al. 2005 [ [34]] 68/822 13/274 1,81 0,98 to 3,33  
Brand et al. 2005 [ [22]] 29/408 15/398 1,95 1,03 to 3,70  
Lakatos et al. 2005 [ [35]] 104/1054 48/400 0,80 0,56 to 1,15  
Gazouli et al. 2005 [ [36]] 19/240 6/200 2,78 1,09 to 7,10  
Oostenbrug et al. 2005 [ [37]] 53/786 27/592 1,51 0,94 to 2,43  
Ouburg et al. 2005 [ [38]] 23/224 18/340 2,04 1,08 to 3,88  
Fries et al. 2005 [ [39]] (1) 2/46 2/118 2,63 0,36 to 19,29  
Fries et al. 2005 [ [39]] (2) 10/120 2/118 5,27 1,13 to 24,60  
Zouiten-Mekki et al. 2009 [ [40]] 12/180 9/160 1,19 0,49 to 2,92  
Hong et al. 2007 [ [41]] 26/364 32/376 0,82 0,48 to 1,42  
Baumgart et al. 2007 [ [21]] (1) 6/288 16/404 0,51 0,20 to 1,33  
Baumgart et al. 2007 [ [21]] (2) 28/482 49/806 0,95 0,59 to 1,54  
Browning et al. 2007 [ [42]] 50/778 44/832 1,23 0,81 to 1,86  
De Ridder et al. 2007 [ [23]] (1) 11/144 20/488 1,93 0,91 to 4,14  
De Ridder et al. 2007 [ [23]] (2) 63/756 20/488 2,12 1,27 to 3,56  
Riis et al. 2007 [ [43]] 32/422 152/1236 0,58 0,39 to 0,87  
Hume et al. 2008 [ [44]] 87/1238 36/720 1,43 0,96 to 2,14  
Rigoli et al. 2008 [ [45]] 10/266 8/206 0,96 0,38 to 2,49  
Manolakis et al. 2013 [ [46]] 20/326 33/548 1,02 0,58 to 1,81  
Current study 2014 9/166 10/224 1,22 0,49 to 3,09  
Total (fixed effects) 825/10676 633/10152 1,26 1,13 to 1,42 0.0001
Total (random effects) 825/10676 633/10152 1,35 1,12 to 1,64