Table 1 Pooled analysis of studies exploring the role of TLR4 Asp299Gly in CD

Arnott et al. 2004 [ [31]]

50/468

33/378

1,25

0,79 to 1,98

Franchimont et al. 2004 [ [32]] (1)

73/668

14/278

2,31

1,28 to 4,17

Franchimont et al. 2004 [ [32]] (2)

26/226

14/278

2,45

1,25 to 4,81

Torok et al. 2004 [ [33]]

14/204

12/290

1,70

0,77 to 3,77

Braat et al. 2005 [ [34]]

68/822

13/274

1,81

0,98 to 3,33

Brand et al. 2005 [ [22]]

29/408

15/398

1,95

1,03 to 3,70

Lakatos et al. 2005 [ [35]]

104/1054

48/400

0,80

0,56 to 1,15

Gazouli et al. 2005 [ [36]]

19/240

6/200

2,78

1,09 to 7,10

Oostenbrug et al. 2005 [ [37]]

53/786

27/592

1,51

0,94 to 2,43

Ouburg et al. 2005 [ [38]]

23/224

18/340

2,04

1,08 to 3,88

Fries et al. 2005 [ [39]] (1)

2/46

2/118

2,63

0,36 to 19,29

Fries et al. 2005 [ [39]] (2)

10/120

2/118

5,27

1,13 to 24,60

Zouiten-Mekki et al. 2009 [ [40]]

12/180

9/160

1,19

0,49 to 2,92

Hong et al. 2007 [ [41]]

26/364

32/376

0,82

0,48 to 1,42

Baumgart et al. 2007 [ [21]] (1)

6/288

16/404

0,51

0,20 to 1,33

Baumgart et al. 2007 [ [21]] (2)

28/482

49/806

0,95

0,59 to 1,54

Browning et al. 2007 [ [42]]

50/778

44/832

1,23

0,81 to 1,86

De Ridder et al. 2007 [ [23]] (1)

11/144

20/488

1,93

0,91 to 4,14

De Ridder et al. 2007 [ [23]] (2)

63/756

20/488

2,12

1,27 to 3,56

Riis et al. 2007 [ [43]]

32/422

152/1236

0,58

0,39 to 0,87

Hume et al. 2008 [ [44]]

87/1238

36/720

1,43

0,96 to 2,14

Rigoli et al. 2008 [ [45]]

10/266

8/206

0,96

0,38 to 2,49

Manolakis et al. 2013 [ [46]]

20/326

33/548

1,02

0,58 to 1,81

Current study 2014

9/166

10/224

1,22

0,49 to 3,09

Total (fixed effects)

825/10676

633/10152

1,26

1,13 to 1,42

0.0001

Total (random effects)

825/10676

633/10152

1,35

1,12 to 1,64