Skip to main content

Table 4 Predictors of rebleeding in patients with small bowel angioectasia

From: Frequency and risk factors for rebleeding events in patients with small bowel angioectasia

Variables

Rebleeding

Univariate (OR 95% CI)

P value

Multivariate (OR 95% CI)

P value

Age >65 years

1.38 (0.54-3.52)

0.50

  

Male sex

2.11 (0.87-5.15)

0.10

2.52 (0.95-6.70)

0.07

Overt bleeding

2.00 (0.79-5.08)

0.14

  

Blood transfusion

3.16 (1.30-7.69)

0.01

1.08 (0.32-3.63)

0.91

Minimum hemoglobin value <8 g/dl

2.03 (0.89-4.60)

0.09

2.43 (0.95-6.19)

0.06

Size of angioectasia ≥1 mm

0.80 (0.36-1.75)

0.57

  

Number of angioectasias ≥3

4.31 (1.60-11.6)

0.004

3.82 (1.30-11.3)

0.02

Drinking history

1.72 (0.75-3.95)

0.20

  

Smoking history

1.71 (0.75-3.87)

0.20

  

Comorbidity

    

Hypertension

1.63 (0.64-4.17)

0.30

  

Diabetes

0.95 (0.35-2.55)

0.92

  

Cardiovascular disease

1.89 (0.80-4.48)

0.15

  

Cerebral infarction

1.68 (0.57-4.95)

0.35

  

CKD stage ≥4

2.94 (1.29-6.71)

0.01

1.72 (0.58-5.06)

0.33

Liver cirrhosis

3.77 (0.87-16.3)

0.08

3.44 (0.60-19.8)

0.17

Medication use

    

Warfarin

3.30 (1.29-8.40)

0.01

2.48 (0.79-7.79)

0.12

LDA

1.00 (0.43-2.31)

>0.99

  

Thienopyridine

1.99 (0.74-5.38)

0.17

  

NSAIDs

1.32 (0.39-4.46)

0.65

  

H2-blockers

0.75 (0.28-2.01)

0.56

  

PPIs

1.45 (0.64-3.32)

0.38

  

Rebamipide

1.17 (0.40-3.45)

0.77

  
  1. NOTE: For the multivariate Cox proportional hazard regression analysis, only the variables that were identified by univariate analysis as being significant with a P value of <0.1 were included as covariates.
  2. Abbreviations: OR, odds ratio; CI, confidence interval; CKD, chronic kidney disease; LDA, low-dose aspirin; NSAIDs, nonsteroidal anti-inflammatory drugs; H2-blockers, histamine H2 receptor antagonists; PPIs, proton pump inhibitors.
  3. Variable definitions: Alcohol history was defined as positive if the subject’s alcohol consumption exceeded 20 g/day. Smoking history was defined as positive if the subject had smoked more than 10-pack years and was still smoking or had quit within the previous 10 years. History of antiplatelet drug and/or NSAID use was defined as positive if the patient had been taking at least 1 pill per day of either of these drugs for more than 1 week within 1 month prior to the CE. History of anticoagulant drug use was defined as positive if the patient had been taking at least 1 pill of anticoagulant drug per day within one week prior to the CE.