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Table 4 Predictors of rebleeding in patients with small bowel angioectasia

From: Frequency and risk factors for rebleeding events in patients with small bowel angioectasia

Variables Rebleeding
Univariate (OR 95% CI) P value Multivariate (OR 95% CI) P value
Age >65 years 1.38 (0.54-3.52) 0.50   
Male sex 2.11 (0.87-5.15) 0.10 2.52 (0.95-6.70) 0.07
Overt bleeding 2.00 (0.79-5.08) 0.14   
Blood transfusion 3.16 (1.30-7.69) 0.01 1.08 (0.32-3.63) 0.91
Minimum hemoglobin value <8 g/dl 2.03 (0.89-4.60) 0.09 2.43 (0.95-6.19) 0.06
Size of angioectasia ≥1 mm 0.80 (0.36-1.75) 0.57   
Number of angioectasias ≥3 4.31 (1.60-11.6) 0.004 3.82 (1.30-11.3) 0.02
Drinking history 1.72 (0.75-3.95) 0.20   
Smoking history 1.71 (0.75-3.87) 0.20   
Comorbidity     
Hypertension 1.63 (0.64-4.17) 0.30   
Diabetes 0.95 (0.35-2.55) 0.92   
Cardiovascular disease 1.89 (0.80-4.48) 0.15   
Cerebral infarction 1.68 (0.57-4.95) 0.35   
CKD stage ≥4 2.94 (1.29-6.71) 0.01 1.72 (0.58-5.06) 0.33
Liver cirrhosis 3.77 (0.87-16.3) 0.08 3.44 (0.60-19.8) 0.17
Medication use     
Warfarin 3.30 (1.29-8.40) 0.01 2.48 (0.79-7.79) 0.12
LDA 1.00 (0.43-2.31) >0.99   
Thienopyridine 1.99 (0.74-5.38) 0.17   
NSAIDs 1.32 (0.39-4.46) 0.65   
H2-blockers 0.75 (0.28-2.01) 0.56   
PPIs 1.45 (0.64-3.32) 0.38   
Rebamipide 1.17 (0.40-3.45) 0.77   
  1. NOTE: For the multivariate Cox proportional hazard regression analysis, only the variables that were identified by univariate analysis as being significant with a P value of <0.1 were included as covariates.
  2. Abbreviations: OR, odds ratio; CI, confidence interval; CKD, chronic kidney disease; LDA, low-dose aspirin; NSAIDs, nonsteroidal anti-inflammatory drugs; H2-blockers, histamine H2 receptor antagonists; PPIs, proton pump inhibitors.
  3. Variable definitions: Alcohol history was defined as positive if the subject’s alcohol consumption exceeded 20 g/day. Smoking history was defined as positive if the subject had smoked more than 10-pack years and was still smoking or had quit within the previous 10 years. History of antiplatelet drug and/or NSAID use was defined as positive if the patient had been taking at least 1 pill per day of either of these drugs for more than 1 week within 1 month prior to the CE. History of anticoagulant drug use was defined as positive if the patient had been taking at least 1 pill of anticoagulant drug per day within one week prior to the CE.