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Table 1 Effect of high-saturate-fat diet and DEN on nutrition status, serum lipid profile and liver function test

From: High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma

Week Group n Body weight (g) Body length (cm) BMI (g/cm 2) TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ALT (U/L) AST (U/L) ALB (g/L)
10 NCD 8 379.00 ± 27.83 24.13 ± 0.64 0.62 ± 0.05 1.47 ± 0.17 0.17 ± 0.05 1.01 ± 0.13 0.89 ± 0.09 42.38 ± 7.76 133.75 ± 22.30 35.24 ± 1.13
HFD 8 486.88 ± 34.50 26.55 ± 0.69 0.66 ± 0.03 2.13 ± 0.50 0.38 ± 0.34 1.45 ± 0.25# 1.39 ± 0.36# 48.38 ± 14.29 172.63 ± 59.49 36.18 ± 2.20
NCD + DEN 7 276.9 ± 40.8^& 23.79 ± 1.19 0.49 ± 0.05^^&& 2.26 ± 0.37^ 0.47 ± 0.18^ 1.17 ± 0.35 1.32 ± 0.25^ 170.01 ± 77.55^& 364.17 ± 261.10 36.16 ± 2.34
HFD + DEN 7 363.13 ± 21.91▲▲ $$ 25.14 ± 0.75▲▲ 0.57 ± 0.03▲▲$$ 4.05 ± 1.41 0.54 ± 0.22 2.27 ± 0.48▲▲** 2.51 ± 1.00** 144.90 ± 22.83**$$ 187.74 ± 17.89 38.96 ± 1.29*$
12 NCD 8 429.50 ± 19.32 25.81 ± 0.70 0.65 ± 0.03 1.58 ± 0.14 0.35 ± 0.15 1.13 ± 0.15 1.02 ± 0.10 36.63 ± 18.12 131.75 ± 28.74 37.25 ± 2.31
HFD 8 531.63 ± 36.62 27.53 ± 0.44 0.70 ± 0.04 2.52 ± 0.55# 0.30 ± 0.11 1.82 ± 0.30## 1.76 ± 0.42# 166.38 ± 72.26## 235.00 ± 58.89## 36.95 ± 2.59
NCD + DEN 7 289.9 ± 65.6^^&& 23.71 ± 2.06 0.51 ± 0.04^^&& 2.55 ± 0.40^ 0.46 ± 0.13 1.32 ± 0.15 1.54 ± 0.18^ 118.64 ± 20.55^^ 258.71 ± 48.22^^ 34.57 ± 3.31
HFD + DEN 7 384.3 ± 28.9▲▲$$ 25.43 ± 0.53 0.59 ± 0.04▲▲$$ 4.64 ± 0.79▲▲** 0.59 ± 0.14*$ 2.77 ± 0.23▲▲** 2.88 ± 0.56▲▲** 149.69 ± 35.13** 272.72 ± 102.56** 38.90 ± 1.17
14 NCD 8 442.20 ± 49.66 26.00 ± 0.91 0.66 ± 0.08 1.75 ± 0.16 0.28 ± 0.18 1.12 ± 0.16 1.09 ± 0.10 53.00 ± 9.62 148.56 ± 27.05 37.15 ± 1.71
HFD 8 571.1 ± 36.58## 27.25 ± 0.75# 0.77 ± 0.03# 2.90 ± 0.63# 0.39 ± 0.14 1.93 ± 0.31## 2.62 ± 0.63## 139.10 ± 63.72# 260.00 ± 90.15# 36.90 ± 0.91
NCD + DEN 9 285.72 ± 53.95^^&& 23.94 ± 1.51^^ 0.50 ± 0.05^^&& 3.16 ± 0.63^^ 0.63 ± 0.23^ 1.61 ± 0.36 1.77 ± 0.37^^& 162.03 ± 34.72^^ 365.11 ± 70.68^^ 36.89 ± 3.07
HFD + DEN 10 386.26 ± 47.71▲▲ $$ 25.75 ± 0.98▲▲ 0.58 ± 0.04▲▲$$ 4.85 ± 0.95▲▲**$$ 0.56 ± 0.20* 2.65 ± 0.25▲▲**$ 3.04 ± 0.69▲▲** 151.86 ± 23.54** 248.90 ± 68.52▲▲* 40.00 ± 1.96*$
  1. NCD: normal chow diet; HFD: high saturate fat diet; DEN: diethylinitrosamine; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin.
  2. HFD + DEN vs NCD + DEN: P < 0.05, ▲▲ P < 0.01; HFD + DEN vs NCD: *P < 0.05, **P < 0.01; HFD + DEN vs HFD: $ P < 0.05, $$ P < 0.01; NCD + DEN vs NCD: ^ P < 0.05, ^^ P < 0.01; NCD + DEN vs HFD: & P < 0.05, && P < 0.01; HFD vs NCD: # P < 0.05, ## P < 0.01.