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Table 1 Clinical presentation, histology, genetics and associated disorders in patients with seronegative celiac disease

From: The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center

Pts Gender Age at diagnosis Clinical phenotype HLA-typing Duodenal biopsy Anti-TG2 AGA Associated disorders
Untreated After GFD EmA DGP
#1 Male 58 Classical DQ2+ 3c 1 Neg IgG + ve Autoimmune thyroiditis
#2 Female 34 Classical DQ2+ 3a 1 Neg IgG + ve PBC
#3 Female 37 Classical DQ2+ 3c 1 Neg Neg None
#4 Female 75 Classical DQ2+ 3c 1 Neg Neg None
#5 Female 45 Classical DQ2+ 3a 1 Neg Neg None
#6 Female 55 Classical DQ2+ 3c 1 Neg IgG + ve Gluten ataxia
#7 Male 61 Classical DQ8+ 3b 1 Neg Neg Peripheral neuropathy
#8 Female 48 Classical DQ2+ 3c 1 Neg Neg None
#9 Female 49 Classical DQ2+ 3a 1 Neg IgG + ve; IgA + ve Autoimmune
gastritis
#10 Female 30 Classical DQ2+ 3b 1 Neg Neg None
#11 Female 63 Classical DQ2+ 3c 1 Neg Neg None
  1. Note: Anti-TG2: tissue transglutaminase antibodies, EmA: endomysial antibodies, DGP: deamidated gliadin antibodies, AGA: gliadin antibodies, GFD; gluten-free diet, PBC; primary biliary cirrhosis; duodenal biopsy scored according to Marsh-Oberhüber classification: "3a", partial; "3b", subtotal; "3c", total villous atrophy; "1" indicates increased intraepithelial lymphocytes.