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Table 1 Sensitivity of histological assessment of Helicobacter pylori infection using PCR analysis as the reference standard, in Portuguese and Mozambican populations of dyspeptic patients.

From: Sensitivity is not an intrinsic property of a diagnostic test: empirical evidence from histological diagnosis of Helicobacter pylori infection

  Helicobacter pyloriinfection
  PCR (reference standard) Histological assessment (index text)
  + + - Sensitivity (95%CI)
All participants     
   Portugal 104 100* 4 96.2 (90.4-98.9)
   Mozambique 95 63† 32 66.3 (55.9-75.7)
Participants not reporting previous eradication treatment     
   Portugal 97 95‡ 2 97.9 (92.7-99.7)
   Mozambique 62 41§ 21 66.1 (53.0-77.7)
Participants not reporting previous PPI/H2 receptor blockers treatment     
   Portugal 75 74# 1 98.7 (92.8-100.0)
   Mozambique 37 22¶ 15 59.4 (42.1-75.2)
Excluding participants reporting previous eradication and PPI/H2 receptor blockers treatments     
   Portugal 97 95** 2 97.9 (92.7-99.7)
   Mozambique 66 42†† 24 63.6 (50.9-75.1)
  1. PCR - Polymerase chain reaction; 95%CI - 95% confidence interval; PPI - Proton pump inhibitors * H. pylori density score: mild (5.0%); moderate (42.0%); marked (53.0%), † H. pylori density score: mild (20.6%); moderate (34.9%); marked (44.4%), ‡ H. pylori density score: mild (5.3%); moderate (42.1%); marked (52.6%), §H. pylori density score: mild (19.5%); moderate (43.9%); marked (36.6%), # H. pylori density score: mild (5.4%); moderate (44.6%); marked (50.0%), ¶H. pylori density score: mild (27.3%); moderate (40.9%); marked (31.8%), ** H. pylori density score: mild (5.3%); moderate (42.1%); marked (52.6%), †† H. pylori density score: mild (21.4%); moderate (42.9%); marked (35.7%)