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Table 7 Results of the genetic association analyses for subgroups stratified by disease presentation and family history of disease.

From: Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer

Subgroups

Gene/Variant

N CRC

N CON

minAFca

minAFco

P allelic

OR allelic

CARD4

       

Colon (Subgroup 1)

ND1+32656

526

720

0.253

0.236

0.336

1.09 [0.91-1.32]

Rectum (Subgroup 2)

ND1+32656

459

720

0.265

0.236

0.117

1.16 [0.96-1.41]

Familial (Subgroup 3)

ND1+32656

187

720

0.283

0.236

0.058

1.28 [0.99-1.65]

Non-Familial (Subgroup 4)

ND1+32656

832

720

0.253

0.236

0.276

1.10 [0.93-1.29]

Colon (Subgroup 1)

E266K

535

709

0.252

0.267

0.423

0.93 [0.77-1.11]

Rectum (Subgroup 2)

E266K

469

709

0.252

0.267

0.418

0.92 [0.77-1.12]

Familial (Subgroup 3)

E266K

188

709

0.247

0.267

0.451

0.90 [0.70-1.18]

Non-Familial (Subgroup 4)

E266K

852

709

0.254

0.267

0.429

0.94 [0.80-1.10]

CARD8

       

Colon (Subgroup 1)

C10Ter

468

722

0.312

0.321

0.632

1.05 [0.89-1.24]

Rectum (Subgroup 2)

C10Ter

537

722

0.332

0.321

0.558

0.96 [0.80-1.14]

Familial (Subgroup 3)

C10Ter

189

722

0.317

0.321

0.886

0.98 [0.77-1.25]

Non-Familial (Subgroup 4)

C10Ter

852

722

0.326

0.321

0.794

1.02 [0.88-1.19]

CARD15

       

Colon (Subgroup 1)

R702W

539

723

0.048

0.046

0.760

1.06 [0.73-1.54]

Rectum (Subgroup 2)

R702W

469

723

0.055

0.046

0.283

1.23 [0.85-1.78]

Familial (Subgroup 3)

R702W

189

723

0.029

0.046

0.155

0.63 [0.33-1.20]

Non-Familial (Subgroup 4)

R702W

855

723

0.056

0.046

0.183

1.24 [0.90-1.72]

Colon (Subgroup 1)

G908R

539

723

0.017

0.012

0.293

1.43 [0.73-2.79]

Rectum (Subgroup 2)

G908R

469

723

0.014

0.012

0.650

1.18 [0.57-2.45]

Familial (Subgroup 3)

G908R

189

723

0.019

0.012

0.305

1.59 [0.65-3.86]

Sporadic (Subgroup 4)

G908R

855

723

0.014

0.012

0.570

1.20 [0.64-2.24]

Colon (Subgroup 1)

L1007fs

539

724

0.040

0.028

0.088

1.46 [0.94-2.26]

Rectum (Subgroup 2)

L1007fs

469

724

0.032

0.028

0.542

1.16 [0.72-1.88]

Familial (Subgroup 3)

L1007fs

189

724

0.042

0.028

0.141

1.55 [0.86-2.81]

Sporadic (Subgroup 4)

L1007fs

855

724

0.035

0.028

0.273

1.26 [0.84-1.89]