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Table 4 Results of the genetic association analyses of the tagging SNPs in the CARD8 gene.

From: Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer

dbSNP id

CARD8

Position

MAF

case

MAF

cont

ORallelic[CI95%]

Pallelic

PHAP2

PHAP3

PHAP4

PHAP5

1044 CRC patients vs 724 sex-matched control individuals

   rs4802445

3'UTR

0.44

0.45

0.95 [0.83-1.08]

0.431

0.549

0.540

0.615

0.305

   rs1966625

intron

0.09

0.10

0.90 [0.72-1.13]

0.360

0.552

0.463

0.368

0.726

   rs16981829

intron

0.33

0.33

1.00 [0.86-1.15]

0.976

0.998

0.419

0.712

0.697

   rs11881179

V68I

0.001

0.001

1.04 [0.17-6.25]

0.964

0.975

0.999

0.971

0.518

   rs4802449

intron

0.34

0.34

0.99 [0.86-1.14]

0.856

0.966

0.828

0.406

0.488

   rs2043211

C10Ter

0.32

0.32

1.01 [0.88-1.17]

0.857

0.907

0.474

0.477

0.549

   rs6509364

intron

0.34

0.34

1.02 [0.88-1.17]

0.820

0.593

0.642

0.661

0.602

   rs11670259

intron

0.35

0.34

1.05 [0.91-1.21]

0.486

0.483

0.592

0.675

0.517

   rs12984929

intron

0.41

0.39

1.09 [0.95-1.25]

0.235

0.545

0.760

0.343

0.417

   rs11672725

intron

0.20

0.19

1.02 [0.86-1.21]

0.819

0.819

0.865

0.350

-#

   rs10500300

intron

0.08

0.08

1.06 [0.83-1.36]

0.619

0.820

0.226

-#

-#

   rs6509368

intron

0.44

0.44

1.02 [0.89-1.16]

0.816

0.544

-#

-#

-#

   rs10405717

intron

0.15

0.17

0.90 [0.75-1.07]

0.238

-#

-#

-#

-#

143 CRC patients (age at diagnosis ≤50) vs 639 sex-matched control individuals

   rs4802445

3'UTR

0.4

0.45

0.81 [0.62-1.05]

0.106

0.197

0.310

0.352

0.321

   rs1966625

intron

0.07

0.1

0.73 [0.45-1.18]

0.200

0.322

0.373

0.388

0.692

   rs16981829

intron

0.31

0.33

0.94 [0.71-1.24]

0.663

0.603

0.388

0.647

0.729

   rs11881179

V68I

0

0.002

N/A*

0.503

0.166

0.280

0.372

0.039

   rs4802449

intron

0.39

0.34

1.25 [0.96-1.63]

0.100

0.232

0.341

0.028

0.131

   rs2043211

C10Ter

0.29

0.32

0.84 [0.63-1.11]

0.225

0.251

0.024

0.144

0.067

   rs6509364

intron

0.32

0.33

0.94 [0.72-1.24]

0.668

0.004

0.031

0.020

0.092

   rs11670259

intron

0.43

0.34

1.46 [1.13-1.90]

0.004 a

0.023

0.018

0.118

0.159

   rs12984929

intron

0.37

0.39

0.93 [0.71-1.21]

0.595

0.865

0.441

0.332

0.407

   rs11672725

intron

0.2

0.2

1.04 [0.75-1.43]

0.830

0.755

0.575

0.615

-#

   rs10500300

intron

0.09

0.08

1.14 [0.72-1.80]

0.583

0.590

0.750

-#

-#

   rs6509368

intron

0.47

0.44

1.1 [0.85-1.42]

0.479

0.585

-#

-#

-#

   rs10405717

intron

0.17

0.16

1.08 [0.77-1.52]

0.648

-#

-#

-#

-#

  1. a P value were not significant after Bonferroni correction for multiple testing, *no odds ratio calculated due to low allele frequency, # p-value is reported for the first marker in the haplotype window. The minor allele frequencies (MAF) for cases and controls are reported. P values and odds ratios are reported for the allelic (pallelic) test. Columns PHAP2 to PHAP5 refer to a sliding window haplotype analysis using COCAPHASE. For example, PHAP5 (0.417) for rs12984929 reports the global significance value for the window 5 haplotype spanning rs12984929-rs11672725- rs10500300- rs6509368- rs10405717.