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Table 3 Results of the association analyses of tagging SNPs in the CARD4 gene.

From: Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer

dbSNP id

CARD4

Position

MAF

case

MAF

cont

ORallelic[CI95%]

Pallelic

PHAP2

PHAP3

PHAP4

PHAP5

1044 CRC patients vs 724 sex-matched control individuals

   Rs5743369

intron

0.15

0.16

0.93 [0.78-1.12]

0.445

0.371

0.252

0.333

0.421

   Rs10267377

intron

0.30

0.28

1.09 [0.94-1.27]

0.253

0.222

0.322

0.556

0.274

   Rs2907748

intron

0.26

0.23

1.14 [0.98-1.34]

0.103

0.415

0.748

0.637

0.546

   ND1+32656

intron

0.26

0.24

1.13 [0.96-1.32]

0.131

0.512

0.405

0.238

0.148

   Rs2907749

intron

0.29

0.27

1.1 [0.95-1.28]

0.234

0.365

0.095

0.112

0.199

   Rs2284358

intron

0.29

0.27

1.09 [0.94-1.26]

0.304

0.618

0.152

0.204

0.184

   Rs2075820

E266K

0.25

0.27

0.93 [0.80-1.09]

0.363

0.666

0.367

0.374

0.294

   Rs7789045

intron

0.46

0.47

0.96 [0.84-1.10]

0.558

0.755

0.366

0.35

0.384

   rs2075819

intron

0.27

0.29

0.92 [0.79-1.07]

0.307

0.092

0.086

0.22

0.343

   rs3823773

intron

0.12

0.12

0.98 [0.79-1.21]

0.891

0.984

0.986

0.864

0.382

   rs736781

intron

0.19

0.19

0.99 [0.83-1.17]

0.919

0.941

0.765

0.283

0.352

   rs2893375

intron

0.17

0.17

1.03 [0.86-1.23]

0.783

0.911

0.162

0.255

0.172

   rs2529440

intron

0.42

0.42

1.02 [0.89-1.17]

0.777

0.364

0.243

0.175

-#

   rs4720004

intron

0.15

0.14

1.13 [0.93-1.37]

0.236

0.525

0.327

-#

-#

   rs932272

intron

0.40

0.39

1.04 [0.91-1.20]

0.536

0.286

-#

-#

-#

   rs17770244

intron

0.06

0.06

1.01 [0.76-1.35]

0.927

-#

-#

-#

-#

143 CRC patients (age at diagnosis ≤ 50) vs 639 sex-matched control individuals

   rs5743369

intron

0.12

0.16

0.7 [0.47-1.03]

0.065

0.069

0.09

0.19

0.22

   rs10267377

intron

0.34

0.29

1.26 [0.96-1.66]

0.093

0.212

0.41

0.55

0.36

   rs2907748

intron

0.28

0.23

1.3 [0.97-1.74]

0.075

0.273

0.52

0.32

0.15

   ND1+32656

intron

0.29

0.24

1.31 [0.98-1.76]

0.065

0.263

0.13

0.04

0.10

   rs2907749

intron

0.32

0.27

1.25 [0.95-1.66]

0.111

0.06

0.007

0.04

0.10

   rs2284358

intron

0.32

0.28

1.25 [0.95-1.65]

0.117

0.01

0.02

0.06

0.07

   rs2075820

E266K

0.19

0.27

0.62 [0.45-0.86]

0.004a

0.009

0.03

0.04

0.06

   rs7789045

intron

0.43

0.47

0.84 [0.65-1.09]

0.188

0.01

0.01

0.04

0.06

   rs2075819

intron

0.21

0.29

0.62 [0.46-0.85]

0.003a

0.005

0.01

0.02

0.04

   rs3823773

intron

0.09

0.12

0.69 [0.44-1.07]

0.098

0.07

0.08

0.11

0.03

   rs736781

intron

0.14

0.2

0.66 [0.46-0.95]

0.025a

0.03

0.05

0.01

0.02

   rs2893375

intron

0.21

0.17

1.3 [0.94-1.79]

0.110

0.07

0.01

0.03

0.02

   rs2529440

intron

0.41

0.42

0.96 [0.74-1.24]

0.750

0.01

0.03

0.02

-#

   rs4720004

intron

0.19

0.14

1.5 [1.07-2.09]

0.017a

0.03

0.03

-#

-#

   rs932272

intron

0.39

0.39

0.98 [0.75-1.28]

0.887

0.76

-#

-#

-#

   rs17770244

intron

0.06

0.06

1.11 [0.65-1.89]

0.704

-#

-#

-#

-#

  1. a P value were not significant after Bonferroni correction for multiple testing, *no odds ratio calculated owing to low allele frequency, # p value reported for the first marker in the haplotype. The minor allele frequencies (MAF) for cases and controls are reported. P values and odds ratios are reported for the allelic (pallelic) test. Columns PHAP2 to PHAP5 refer to a sliding window haplotype analysis using COCAPHASE. For example, PHAP3 (0.252) for rs5743369 reports the global significance value for the window 3 haplotype spanning rs5743369- rs10267377- rs2907748.