Table 2 Overview and clinicopathologic characteristics of the cohorts and subgroups used in the present study.
Sample | N | Median age | Median age at diagnosis | %male |
|---|---|---|---|---|
Cases (total cohort) | 1044 | 63 | 59 | 50% |
   Tumour location |  |  |  |  |
Colon (Subgroup 1) | 539 | 63 | 59 | 47% |
Rectum (Subgroup 2) | 469 | 63 | 59 | 53% |
Rectum and remaining colon | 36 | 64 | 59 | 50% |
   Family history |  |  |  |  |
Familial CRC (Subgroup 3) | 189 | 64 | 60 | 45% |
Non-Familial CRC (Subgroup 4) | 855 | 63 | 59 | 51% |
   Cases (age at diagnosis ≤ 60) | 337 | 60 | 56 | 50% |
   Cases (age at diagnosis ≤ 50) | 143 | 49 | 45 | 43% |
   Cases (age at diagnosis ≤ 45) | 72 | 45 | 41 | 42% |
   Cases (age at diagnosis > 50) | 901 | 64 | 60 | 50% |
Controls (sexmatched to the total cohort) | 724 | 68 | / | 50% |
Controls (sexmatched to case ≤ 50) | 639 | 68 | / | 43% |