Table 1 Summary of association analyses and overview of allele frequencies of CARD15 mutations stratified by age and population.
--------------------------Current study--------------------------- | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Country, Ref. | Poland, [15] | Poland, [15] | Finnland, [18] | Germany | Germany | Germany | Germany | Germany | Greece, [16] | New Zealand, [17] | Hungary, [20] | Finnland, [18] |
|  | Age at diagnosis | >50 | ≤ 50 | ≤ 50 | ≤ 45 | ≤ 50 | ≤ 60 | >50 | total | total | total | total | total |
| Â | N CRC | 250 | 50 | 68 | 72 | 143 | 597 | 901 | 1044 | 104 | 133 | 194 | 953(926*) |
| Â | N controls | 300 | 300 | 348 | 724 | 724 | 724 | 724 | 724 | 100 | 201 | 200 | 348 |
R702W | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CRC | % Allele freq. | / | / | / | 9.7 | 7.7 | 5.4 | 4.7 | 5.1 | 4.8 | 7.1 | 1.8 | 2.2 |
Controls | % Allele freq. | / | / | / | 4.6 | 4.6 | 4.6 | 4.6 | 4.6 | 1 | 3 | 1.5 | 2.1 |
| Â | p value | / | / | / | 0.008 | 0.03 | 0.30 | 0.83 | 0.5 | 0.02 | 0.03 | 0.78 | 0.88 |
| Â | ORAllelic | / | / | / | 2.22 | 1.75 | 1.2 | 1.04 | 1.13 | 5.21 | 2.3 | 1.21 | 1.04 |
| Â | [95% CI] | Â | Â | Â | [1.21--4.05] | [1.05--2.91] | [0.85--1.71] | [0.74--1.44] | [0.82--1.55] | [1.11--24.23] | [1.1--5] | [0.39--3.67] | [0.61 -- 1.78] |
G908R | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CRC | % Allele freq. | / | / | / | 2.1 | 2.1 | 1.4 | 1.4 | 1.5 | 8.65 | 2.2 | 1.8 | 0.3 |
Controls | % Allele freq. | / | / | / | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 3.5 | 0.8 | 1.8 | 0.2 |
| Â | p value | / | / | / | 0.35 | 0.36 | 0.57 | 0.59 | 0.43 | 0.025 | 0.09 | 0.95 | 0.57 |
| Â | ORAllelic | / | / | / | 1.79 | 1.69 | 1.22 | 1.18 | 1.27 | 2.78 | 3.1 | 1.03 | 1.59 |
| Â | [95% CI] | Â | Â | Â | [0.52--6.19] | [0.66--4.36] | [0.62--2.39] | [0.64--2.20] | [0.70--2.30] | [1.11--6.98] | [7.7--12.7] | [0.35--3.00] | [0.32 -- 7.91] |
3020InsC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CRC | % Allele freq. | 14.4** | 2** | 2.2 | 5.6 | 3.8 | 3.9 | 3.6 | 3.6 | 12.5 | 2.2 | 3.6 | 1.9 |
Controls | % Allele freq. | 7** | 7** | 1.9 | 2.8 | 2.8 | 2.8 | 2.8 | 2.8 | 6 | 1 | 2.5 | 1.9 |
| Â | p value | 0.0046 | 0.3 | 0.78 | 0.06 | 0.32 | 0.09 | 0.21 | 0.17 | 0.017 | 0.19 | 0.4 | 0.96 |
| Â | ORAllelic | 2.23 | 0.27 | 0.78 | 2.07 | 1.42 | 1.44 | 1.29 | 1.31 | 2.44 | 2.3 | 1.48 | 0.98 |
| Â | [95% CI] | [1.23--4.10] | [0.01--1.97] | [0.17--3.54] | [0.95--4.51] | [0.71--2.83] | [0.94--2.21] | [0.87--1.93] | [0.89--1.93] | [1.15--5.17] | [0.64--8.4] | [0.64--3.41] | [0.51 -- 1.88] |