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Table 4 Frequency distribution of the TGFB1 and VEGF haplotype alleles between gastric cancer cases and controls and their associations with risk of Gastric Cancer

From: The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer

 

Cases

Controls

  

Genotypes

n

%

n

%

Crude OR

(95% CI) *

P**

TGFB1 alleles

(No. of variant alleles)

  

   C-T-G

194

46.0

387

40.0

1.29 (0.12-13.7)

0.830

   C-C-G

107

25.4

216

24.6

1.26 (0.11-13.9)

0.851

   T-C-G

56

13.3

144

16.4

1.93 (0.17-21.8)

0.594

   C-C-C

22

5.21

40

4.6

0.87 (0.06-13.6)

0.919

VEGF alleles

(No. of variant alleles)

  

   C-G-C

135

24.6

278

30.0

0.56 (0.02-18.0)

0.744

   T-C-C

115

20.9

200

21.6

0.42 (0.02-13.6)

0.621

   C-C-C

65

11.8

90

9.7

0.46 (0.01-19.9)

0.686

   C-G-T

35

6.4

45

4.9

0.25 (0.01-12.2)

0.482

  1. * Calculated by using the most common haplotype as the reference. Ors represent the risk per copy of each haplotype.
  2. † The number of TGFB1 haplotype alleles; the variant (risk) alleles used for calculation were-509T, 869C or 915C.
  3. ‡ The number of VEGF haplotype alleles; the variant (risk) alleles used for calculation were -1498C, -634C or 936T.
  4. **Two-sided χ 2 test for the ORs obtained from the multivariate logistic regression with adjustment for age, sex, ethnicity, smoking status and alcohol status