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Table 3 Stratification analysis of gastric cancer risk associated with the VEGF -634 G>C genotype frequencies

From: The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer

 

Cases (n = 171)

Controls (n = 353)

Adjusted OR (95% CI)*

 

Variables

GG

N (%)

CG+CC

N (%)

GG

N (%)

CG+CC

N (%)

GG

CG+CC

P

Age (years)

       

   ≤ 57

30 (42.3)

41 (57.7)

95 (52.8)

85 (47.2)

1.00

1.50 (0.84-2.64)

0.160

   > 57

39 (39.0)

61 (61.0)

85 (49.1)

88 (50.9)

1.00

1.58 (0.95-2.63)

0.080

Sex

       

   Female

18 (32.1)

38 (67.9)

49 (47.1)

55 (52.9)

1.00

1.86 (0.94-3.69)

0.075

   Male

51 (44.4)

64 (55.6)

131 (52.6)

118 (47.4)

1.00

1.44 (0.91-2.28)

0.116

Ethnicity

       

   Hispanic White

53 (44.2)

67 (55.8)

129 (50.0)

129 (50.0)

1.00

1.32 (0.85-2.06)

0.219

   Non-white

16 (31.4)

35 (68.6)

51 (53.7)

44 (46.3)

1.00

2.39 (1.15-4.98)

0.020

Smoking status

       

   Never

27 (38.6)

43 (61.4)

79 (46.7)

90 (53.3)

1.00

1.33 (0.75-2.38)

0.336

   Ever

42 (41.6)

59(58.4)

101 (54.9)

83 (45.1)

1.00

1.74 (1.06-2.90)

0.032

Drinking status

       

   Never

25 (33.3)

50 (66.7)

99 (51.3)

94 (48.7)

1.00

2.00 (1.14-3.54)

0.017

   Ever

44 (45.8)

52 (54.2)

81 (50.6)

79 (49.4)

1.00

1.24 (0.74-2.07)

0.411

  1. * Adjusted for age, sex, ethnicity, smoking status and alcohol status in a logistic regression model where it was appropriate.
  2. Two-sided χ 2 test for the ORs obtained from the multivariate logistic regression with adjustment for age, sex, ethnicity, smoking status and alcohol status