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Table 1 Serum ALT levels in ALF mice

From: The roles of tumor necrosis factor-alpha in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failure

   2 h 6 h 9 h 12 h 24 h
Groups Number of mice ALT ALT ALT ALT ALT
   (U/L) (U/L) (U/L) (U/L) (U/L)
NS 8 30.0 ± 0.3 29.3 ± 1.0 36.8 ± 2.3 32.5 ± 0.7 30.7 ± 0.4
LPS 8 29.4 ± 0.8 27.1 ± 2.0 40.7 ± 7.0 34.5 ± 3.4 29.1 ± 1.7
GalN 8 44.2 ± 0.4 63.4 ± 1.0 110.1 ± 2.5 97.4 ± 1.2 164.1 ± 10.6
GalN/LPS 8 22.2 ± 2.8 2513.2 ± 874.2a 6235.5 ± 912.4a 10215.8 ± 967.7a 10250.6 ± 1045.8a
TNF-alpha 8 34.3 ± 3.4 32.7 ± 4.6 33.4 ± 2.1 34.6 ± 3.9 30.9 ± 8.8
GalN/TNFalpha 8 33.7 ± 2.9 204.1 ± 82.1a 4774.8 ± 1118.0a 6177.8 ± 1280.9a 4204.6 ± 1118.6a
anti-TNF-alpha-IgG+GalN/LPS 8 -- -- 257.1 ± 83.2b -- --
anti-TNF-alpha R-IgG+GalN/LPS 8 -- -- 907.3 ± 551.6b -- --
  1. All values are expressed as mean ± SE. a: P < 0.01 vs Saline group, b: P < 0.01 vs GalN/LPS co-injection group