Table 1 Baseline parameters and relative changes after 60 min, expressed as % of the baseline value
From: Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver
parameter | control | sildenafil 100 μg/kg | sildenafil 10 μg/kg | sildenafil 1 μg/kg | vardenafil 100 μg/kg | vardenafil 10 μg/kg | vardenafil 1 μg/kg | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAP (mmHg) | 84.19 [80.3-88.0] | -0.3 [-3.8-3.2] | 85.0 [80.2-89.7] | -2.6 [-6.5-1.2] | 84.9 [81.7-88.2] | -3.9 ✸ [-7.6 - -0.0] | 83.9 [81.2-86.5] | 1.1 ✸ [0.4-1.9] | 82.9 [79.7-86.2] | -7.4 [-16.3-1.4] | 80.9 [77.5-84.3] | -8.7 ✸ [-15.0 - -2.4] | 88.0 [82.5-93.5] | -11.0 ✸ [-16.7 - -5.3] |
HR (1/min) | 366.4 [348.8-384.1] | -1.1 [-2.9-0.7] | 375.0 [351.0-399.0] | -1.9 [-3.0-6.7] | 375.7 [364.3-387.2] | 3.2 [-0.0-0.1] | 366.0 [332.2-399.8] | 2.9 [-2.1-3.9] | 368.3 [353.3-383.4] | 2.4 [-1.3-6.2] | 362.9 [353.3-372.4] | 5.2 [-3.4-13.7] | 346.0 [324.3-367.7] | 1.3 [-3.4-6.0] |
SVR (mmHg/ml·min) | 0.7 [0.6-0.8] | -4.0 [-10.1-2.1] | 0.7 [0.61-0.77] | -2.0 [-7.8-3.8] | 0.8 [0.68-0.90] | -7.7 ✸ [-12.1 - -3.3] | 0.8 [0.7-0.9] | -0.7 [-8.5-7.1] | 0.7 [0.6-0.8] | -8.7 ✸ [-13.6 - -3.8] | 0.7 [0.5-0.8] | -11.6 ✸ [-20.6 - -2.7] | 0.7 [0.5-0.8] | -11.6 ✸ [-22.1 - -1.1] |
CO (ml/min) | 116.7 [98.4-135.0] | 4.4 [-2.2-10.9] | 120.3 [108.6-131.9] | -0.8 [-4.5-2.9] | 106.7 [90.0-123.4] | 3.7 [-0.1-7.5] | 104.1 [85.33-122.9] | 2.3 [7.0-11.6] | 113.0 [100.0-126.0] | 1.3 [-3.8-6.4] | 119.7 [99.1-140.4] | 3.5 [-2.0-9.1] | 127.5 [103.8-151.2] | 0.4 [-6.0-6.9] |
A hep Resist (mmHg/ml·min) | 20.8 [15.9-25.8] | 0.8 [-13.9-15.5] | 20.3 [14.8-25.8] | -17.4 ✸ [-32.8 - -2.1] | 25.1 [19.3-30.9] | -32.2 ✸ [-47.8 - -16.7] | 23.3 [16.1-30.5] | -1.8 [-6.9-3.2] | 23.4 [18.6-28.2] | -21.8 ✸ [-35.2 - -8.4] | 20.7 [16.5-24.9] | -30.1 ✸ [-41.2 - -18.9] | 16.9 [13.5-20.2] | -18.8 ✸ [-28.1 - -9.5] |
A hep Flow (ml/min) | 4.1 [3.2-5.1] | 0.9 [-12.0-13.9] | 4.4 [3.1-5.6] | 21.3 [-0.0-42.6] | 3.5 [2.6-4.4] | 47.5 ✸ [17.8-77.2] | 3.7 [2.7-4.7] | 3.3 [-2.6-9.1] | 3.5 [2.8-4.3] | 20.2 ✸ [3.2-37.2] | 3.9 [3.2-4.6] | 33.5 ✸ [11.6-55.5] | 5.1 [4.2-6.1] | 9.6 [-5.4-24.7] |
Port Resist (mmHg/ml·min) | 0.2 [0.1-0.2] | 2.8 [-1.9-7.5] | 0.1 [0.11-0.14] | -20.3 [-34.5 - -6.2] | 0.1 [0.1-0.2] | -33.8 ✸ [-46.8 - -20.8] | 0.2 [0.1-0.2] | 0.8 [-7.0-8.5] | 0.1 [0.1-0.2] | -22.0 ✸ [-34.0 - -10.0] | 0.2 [0.1-0.2] | -31.0 ✸ [-40.6 - -21.4] | 0.2 [0.1-0.2] | -38.6 ✸ [-61.1 - -16.0] |
Port Flow (ml/min) | 23.3 [20.1-26.5] | -1.3 [-0.5-2.9] | 25.0 [21.7-28.3] | 18.3 ✸ [2.0-34.5] | 25.3 [22.9-27.7] | 24.1 ✸ [13.3-34.9] | 21.7 [17.6-25.7] | 3.3 [-2.4-8.9] | 22.7 [20-6 - 24-8] | 23.9 ✸ [12.5-35.4] | 24.1 [21.1-27.1] | 29.2 ✸ [22.5-35.9] | 24.0 [21.1-26.9] | 15.9 [-4.6-36.5] |
Parench Flow (ml/min) | 135.2 [121.0-149.4] | -3.9 [-14.0-6.2] | 151.8 [130.5-173.0] | 12.4 ✸ [2.5-22.2] | 133.7 [115.4-151.9] | 15.3 ✸ [9.8-20.8] | 131.3 [122.2-140.5] | 6.3 ✸ [-1.9-14.5] | 126.3 [103.2 -.149.4] | 28.8 ✸ [10.4-47.3] | 146.2 [118.2-174.1] | 15.0 ✸ [1.8-28.2] | 130.1 [114.1-146.0] | 6.8 [-10.0-23.6] |
Port Pressure (mmHg) | 6.3 [5.7-6.9] | -0.8 [-5.7-4.1] | 6.1 [5.5-6.7] | -1.3 [-6.9-4.3] | 6.1 [5.9-6.3] | -6.2 [-13.6-1.3] | 5.7 [4.8-6.6] | 1.0 [-1-8 - 3-9] | 6.3 [5.8-6.7] | -6.8 [-15.0-1.3] | 6.4 [5.7-7.1] | -7.5 [-14.2 - -0.1] | 6.3 [5.3-7.4] | -11.2 [-24.8-2.4] |
Fract Liver Flow (%) | 23.8 [20.6-27.0] | -4.8 [-12.6-3.0] | 24.5 [21.7-27.3] | 19.3 ✸ [5.6-32.9] | 27.5 [23.7-31.3] | 22.9 ✸ [11.6-34.2] | 24.5 [19.5-29.6] | 1.4 [-8.6-11.4] | 23.6 [19.2-28.0] | 22.0 ✸ [10.9-33.2] | 23.7 [21.3-26.0] | 25.5 ✸ [15.9-35.1] | 23.3 [18.1-28.5] | 14.5 [-3.7-32.7] |