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Table 3 Summary of the evidence for HNF4α regulation of intestinally expressed genes

From: Mapping of HNF4α target genes in intestinal epithelial cells

Gene (Gene symbol) mRNA up-regulation during1 ChIP-chip2 ChIP q-PCR3 ChIP q-PCR3
  Caco-2 differentiation Caco2 Caco2 Mouse
Cdx-2 (CDX2) 3.0 5.0 1.9 2.9
Trehalase (TREH) 3.5 4.1 1.9 3.2
Cingulin (CGN) 3.1 4.9 4.3 0.3
Apolipoprotein CIII (APOC3) 9.9 5.3 NA 3.9
HNF1α (TCF1) 1.6 4.7 NA 6.2
Phosphoenolpyruvate 7.7 5.6 NA 4.4
carboxykinase 1 (PCK1)     
  1. 1Fold up-regulation of mRNA during Caco2 cell differentiation. Data were obtained from gene array expression analysis of undifferentiated and differentiated Caco2 cells.2ChIP-chip enrichment of HNF4α target DNA compared to genomic DNA. The data are presented as fold enrichments between HNF4α immunoprecipitated DNA and genomic DNA. 3q-PCR analysis of the HNF4α immunoprecipitated DNA shown as fold enrichment of the HNF4α IP DNA compared to genomic DNA (IgG intron). Array data can be downloaded from NCBI's GEO under the series accession number: GSE7745.