Skip to main content

Advertisement

Table 2 Distribution of HNF4α targets in selected Gene Ontology categories

From: Mapping of HNF4α target genes in intestinal epithelial cells

51179 (localization)
6810 (transport) (no)
   6869 (lipid transport)(N = 16 E = 9 p = 0.026)
   15849 (organic acid transport)(N = 18 E = 10 p = 0.015)
48193 (Golgi vesicle transport)(N = 24 E = 15 p = 0.052)
15837 (amine transport)(N = 16 E = 8 p = 0.012)
6865 (amino acid transport)(N = 15 E = 7 p = 0.014)
8152 (metabolism)
44237 (cellular metabolism) (no)
   6066 (alcohol metabolism)(N = 47 E = 32 p = 0.020)
   51186 (cofactor metabolism) (no)
6732 (coenzyme metabolism)(N = 27 E = 19 p = 0.076)
9109 (coenzyme catabolic process)(N = 7 E = 3 p = 0.049)
6084 (acetyl-CoA metabolism)(N = 11 E = 3 p = 0.001)
   6091 (generation of precursor metabolites and energy)(N = 92 E = 68 p = 0.007)
6118 (electron transport)(N = 59 E = 41 p = 0.009)
6119 (oxidative phosphorylation)(N = 14 E = 8 p = 0.049)
   6082 (organic acid metabolism)(N = 80 E = 54 p = 0.001)
19752 (carboxylic acid metabolism)(N = 80 E = 54 p = 0.001)
   9308 (amine metabolism)(N = 55 E = 43 p = 0.073)
   6519 (amino acid and derivative metabolism)(N = 47 E = 35 p = 0.057)
   6725 (aromatic compound metabolism) (no)
19439 (aromatic compound catabolism)(N = 6 E = 2 p = 0.008)
43170 (macromolecule metabolism) (no)
   9059 (macromolecule biosynthesis)(N = 124 E = 83 p = 3.5E-05)
6259 (DNA metabolism)(N = 112 E = 80 p = 0.001)
51052 (regulation of DNA metabolism)(N = 10 E = 5 p = 0.039)
6323 (DNA packaging)(N = 46 E = 34 p = 0.054)
6325 (establishment and/or maintenance of chromatin architecture)(N = 46 E = 33 p = 0.034)
6310 (DNA recombination)(N = 18 E = 10 p = 0.027)
6281 (DNA repair)(N = 43 E = 29 p = 0.019)
6260 (DNA replication)(N = 30 E = 22 p = 0.079)
16070 (RNA metabolism)(N = 87 E = 65 p = 0.011)
6399 (tRNA metabolism)(N = 19 E = 10 p = 0.009)
6396 (RNA processing)(N = 69 E = 54 p = 0.051)
6519 (amino acid and derivative metabolism)(N = 47 E = 35 p = 0.057)
   19538 (protein metabolism) (no)
6412 (protein biosynthesis)(N = 117 E = 75 p = 1.0E-05)
6418 (tRNA aminoacylation for protein translation)(N = 11 E = 5 p = 0.031)
6414 (translational elongation)(N = 7 E = 3 p = 0.034)
6457 (protein folding)(N = 44 E = 31 p = 0.028)
   6629 (lipid metabolism)(N = 92 E = 70 p = 0.015)
6631 (fatty acid metabolism)(N = 27 E = 18 p = 0.040)
50790 (regulation of enzyme activity)
43086 (negative regulation of enzyme activity)(N = 14 E = 7 p = 0.025)
   6469 (negative regulation of protein kinase activity)(N = 10 E = 5 p = 0.041)
   45859 (regulation of protein kinase activity)(N = 25 E = 17 p = 0.088)
79 (regulation of cyclin dependent protein kinase activity)(N = 12 E = 5 p = 0.011)
6469 (negative regulation of protein kinase activity)(N = 10 E = 5 p = 0.041)
  1. N is the number of identified HNF4α targets assigned with the GO-term indicated. E is the expected number of genes to be found in the GO category. p is the p-value from a Fisher Exact test for the over-representation of HNF4α target genes in the GO category. "no" indicates the higher level GO categories are not over-represented by HNF4α target genes. but contain lower level GO categories with over-representation. A full list of all GO categories with over-representation is presented in additional file 3