Table 2 Distribution of HNF4α targets in selected Gene Ontology categories

51179 (localization)

6810 (transport)

(no)

   6869 (lipid transport)(N = 16 E = 9 p = 0.026)

   15849 (organic acid transport)(N = 18 E = 10 p = 0.015)

48193 (Golgi vesicle transport)(N = 24 E = 15 p = 0.052)

15837 (amine transport)(N = 16 E = 8 p = 0.012)

6865 (amino acid transport)(N = 15 E = 7 p = 0.014)

8152 (metabolism)

44237 (cellular metabolism) (no)

   6066 (alcohol metabolism)(N = 47 E = 32 p = 0.020)

   51186 (cofactor metabolism) (no)

6732 (coenzyme metabolism)(N = 27 E = 19 p = 0.076)

9109 (coenzyme catabolic process)(N = 7 E = 3 p = 0.049)

6084 (acetyl-CoA metabolism)(N = 11 E = 3 p = 0.001)

   6091 (generation of precursor metabolites and energy)(N = 92 E = 68 p = 0.007)

6118 (electron transport)(N = 59 E = 41 p = 0.009)

6119 (oxidative phosphorylation)(N = 14 E = 8 p = 0.049)

   6082 (organic acid metabolism)(N = 80 E = 54 p = 0.001)

19752 (carboxylic acid metabolism)(N = 80 E = 54 p = 0.001)

   9308 (amine metabolism)(N = 55 E = 43 p = 0.073)

   6519 (amino acid and derivative metabolism)(N = 47 E = 35 p = 0.057)

   6725 (aromatic compound metabolism) (no)

19439 (aromatic compound catabolism)(N = 6 E = 2 p = 0.008)

43170 (macromolecule metabolism) (no)

   9059 (macromolecule biosynthesis)(N = 124 E = 83 p = 3.5E-05)

6259 (DNA metabolism)(N = 112 E = 80 p = 0.001)

51052 (regulation of DNA metabolism)(N = 10 E = 5 p = 0.039)

6323 (DNA packaging)(N = 46 E = 34 p = 0.054)

6325 (establishment and/or maintenance of chromatin architecture)(N = 46 E = 33 p = 0.034)

6310 (DNA recombination)(N = 18 E = 10 p = 0.027)

6281 (DNA repair)(N = 43 E = 29 p = 0.019)

6260 (DNA replication)(N = 30 E = 22 p = 0.079)

16070 (RNA metabolism)(N = 87 E = 65 p = 0.011)

6399 (tRNA metabolism)(N = 19 E = 10 p = 0.009)

6396 (RNA processing)(N = 69 E = 54 p = 0.051)

6519 (amino acid and derivative metabolism)(N = 47 E = 35 p = 0.057)

   19538 (protein metabolism) (no)

6412 (protein biosynthesis)(N = 117 E = 75 p = 1.0E-05)

6418 (tRNA aminoacylation for protein translation)(N = 11 E = 5 p = 0.031)

6414 (translational elongation)(N = 7 E = 3 p = 0.034)

6457 (protein folding)(N = 44 E = 31 p = 0.028)

   6629 (lipid metabolism)(N = 92 E = 70 p = 0.015)

6631 (fatty acid metabolism)(N = 27 E = 18 p = 0.040)

50790 (regulation of enzyme activity)

43086 (negative regulation of enzyme activity)(N = 14 E = 7 p = 0.025)

   6469 (negative regulation of protein kinase activity)(N = 10 E = 5 p = 0.041)

   45859 (regulation of protein kinase activity)(N = 25 E = 17 p = 0.088)

79 (regulation of cyclin dependent protein kinase activity)(N = 12 E = 5 p = 0.011)

6469 (negative regulation of protein kinase activity)(N = 10 E = 5 p = 0.041)