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Table 2 Clinical characteristics of latent CD – patient chart review.

From: Symptoms and signs in individuals with serology positive for celiac disease but normal mucosa

  EMA;
N = 38
AGA;
N = 36
TTGA;
N = 38
Total;
N = 112
Total Weighted
N = 3,736
Background data      
Females 26 (68) 24 (67) 25 (66) 75 (67) -
Age at first biopsy: median, range (years) 13 (2–80) 34 (1–91) 34 (1–75) 29 (1–91) -
Year of biopsy, median* 2003 2001 2006 2004 -
Reported heredity for CD 12 (32) 7 (19) 6 (16) 25 (22) 20%
Other diseases      
Diabetes Mellitus, type 1 3 (8) 1 (3) 4 (10) 8 (7) 3%
Depression 1 (3) 4 (11) 8 (21) 13 (12) 11%
Thyroid disease 2 (5) 3 (8) 7 (18) 12 (11) 9%
Liver disease or increased liver enzymes 3 (8) 4 (11) 4 (10) 11 (10) 11%
Symptoms      
Any gastrointestinal symptom# 31 (82) 32 (89) 32 (84) 95 (85) 88%
Diarrhea 16 (42) 18 (50) 17 (45) 51 (46) 49%
Weight loss/growth failure 9 (24) 7 (20) 7 (18) 23 (20) 20%
Abdominal pain 14 (37) 18 (50) 18 (47) 50 (45) 49%
Constipation 10 (26) 4 (11) 6 (16) 20 (18) 12%
Fatigue 6 (16) 6 (17) 5 (13) 17 (15) 16%
Laboratory data      
Anemia and/or iron-deficiency 5 (13) 12 (33) 12 (32) 29 (26) 32%
Folic acid deficiency 2 (5) 0 (0) 4 (10) 6 (5) 1%
B12-deficiency 4 (10) 2 (6) 5 (13) 11 (10) 6%
Erythrocyte sedimentation rate, increased 0 (0) 2 (6) 3 (8) 5 (4) 5%
  1. Percentages are given within brackets. Although latent CD was evaluated in 120 individuals, data on symptoms and signs (± laboratory measures) were only available in 112 individuals (93.3%).
  2. EMA = Endomysial antibodies. AGA = Antigliadin antibodies. TTGA = Tissue transglutaminase antibodies.
  3. Weighted percentages were estimated to mirror the full sample of study participants.
  4. *Only for year of biopsy was there a statistically significant difference according to CD serology subtype when we corrected for multiple testing (Bonferroni correction [20]. There was no statistically significant difference in prevalence of any symptom or sign according to CD serology subtype.
  5. #Weight loss was included among "any GI symptom". Also reflux symptoms (not listed above); nausea and abdominal gases were included among "any GI symptoms".
  6. Additional information: Two individuals had a diagnosis of inflammatory bowel disease (IBD), both were positive for TTGA. Another two individuals had a diagnosis of dermatitis herpetiformis, both were positive for EMA.