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Table 4 Genotype frequencies for PTPN11 rs2301756 polymorphism, odds ratios (ORs) and 95% confidence intervals (CIs) of gastric atrophy in the H. pylori seropositive subjects (a) and H.pylori infected subjects (b)

From: Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pyloriseropositivity, gastric atrophy and gastric cancer in Japanese

(a)          
Genotype, allele n All gastric atrophy (%) ORa 95% CI Pvalueb Severe gastric atrophy (%) ORb 95% CI Pvalueb
G/G 643 350 (54.4) 1 Reference - 127 (19.8) 1 Reference -
G/A 266 131 (49.2) 0.82 0.62–1.10 0.194 38 (14.3) 0.70 0.47–1.04 0.079
A/A 28 14 (50.0) 0.84 0.39–1.81 0.650 3 (10.7) 0.56 0.17–1.91 0.356
G/A+A/A 294 145 (49.3) 0.83 0.62–1.09 0.182 41 (13.9) 0.68 0.46–1.01 0.057
G 1552 831 (53.5) 1 Reference - 292 (18.8) 1 Reference -
A 322 159 (49.4) 0.85 0.66–1.08 0.097 44 (13.7) 0.67 0.45–0.96 0.015
(b)          
Genotype, allele n All gastric atrophy (%) OR a 95% CI P value b Severe gastric atrophy (%) OR a 95% CI P value b
G/G 677 383 (56.6) 1 Reference - 151 (22.3) 1 Reference -
G/A 274 139 (50.7) 0.80 0.60–1.06 0.123 41 (15.0) 0.63 0.43–0.93 0.019
A/A 28 14 (50.0) 0.77 0.36–1.67 0.512 3 (10.7) 0.49 0.14–1.67 0.254
G/A+A/A 302 153 (50.7) 0.80 0.60–1.05 0.106 44 (14.6) 0.62 0.42–0.90 0.012
G 1628 905 (55.6) 1 Reference - 343 (21.1) 1 Reference -
A 330 167 (50.6) 0.82 0.64–1.05 0.102 47 (14.2) 0.62 0.44–0.87 0.005
  1. aOR for each genotype was calculated by age and sex adjusted logistic regression model, and a crude OR was calculated for each allele.
  2. b P values less than 0.05 are shown in Italics.