Figure 2

Effect of lafutidine (10 and 30 mg/kg), relative to vehicle, on the number of c-Fos positive cells in (A) the nucleus tractus solitarii (NTS) and (B) area postrema (AP), (C) macroscopic gastric mucosal injury (expressed as a percentage of the area of the glandular mucosa) and (D) intragastric pH measured 2 h after exposure of the stomach to HCl (0.25 M). Lafutidine or vehicle was administered by gastric gavage 30 min before administration of HCl. The values represent means + SEM, n = 8 if not stated otherwise. * P ≤ 0.1, ** P ≤ 0.05 versus vehicle.