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Table 4 The effect modification between COX-2 -1195G/A polymorphism and seropositivity of H. pylori on the risk of ESCC at lower third of the esophagus and all cancers

From: Polymorphism in COX-2 modifies the inverse association between Helicobacter pyloriseropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study

COX-2 polymorphism Lower third ESCC cases Total ESCC cases
  H. pylori-negative H. pylori-positive H. pylori (+) vs. (-) OR ratio (95% CI) H. pylori-negative H. pylori-positive H. pylori (+) vs. (-) OR ratio (95% CI)
  Cases/Controls AOR1 (95% CI) Cases/Controls AOR1 (95% CI)   Cases/Controls AOR1 (95% CI) Cases/Controls AOR1 (95% CI)  
GG+AG 20/72 1.0 17/81 1.0 (0.4 – 2.5) 1.0 (0.4 – 2.5) 73/72 1.0 46/81 0.7 (0.4 – 1.4) 0.7 (0.4 – 1.4)
AA 18/20 6.9 (2.1 – 22.5) 3/21 0.6 (0.1 – 2.8) 0.09 (0.02 – 0.47) 41/20 2.9 (1.2 – 7.3) 20/21 0.9 (0.4 – 2.1) 0.3 (0.1 – 0.9)
AA vs. GG+AG OR ratio (95% CI)   6.9 (2.1 – 22.5)   0.6 (0.1 – 2.7)    2.9 (1.2 – 7.3)   1.2 (0.5 to 3.0)  
p for interaction2     0.008      0.172  
  1. 1 Odds ratios were adjusted for the covariates (age, gender, education level, pack-years of cigarette smoking and of betel quid chewing, and drink-years of alcohol drinking) listed in Table 1.
  2. 2Interaction was examined with likelihood ratio test for cross-product terms based on a multiplicative model.
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