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Table 4 The effect modification between COX-2 -1195G/A polymorphism and seropositivity of H. pylori on the risk of ESCC at lower third of the esophagus and all cancers

From: Polymorphism in COX-2 modifies the inverse association between Helicobacter pyloriseropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study

COX-2 polymorphism

Lower third ESCC cases

Total ESCC cases

 

H. pylori-negative

H. pylori-positive

H. pylori (+) vs. (-) OR ratio (95% CI)

H. pylori-negative

H. pylori-positive

H. pylori (+) vs. (-) OR ratio (95% CI)

 

Cases/Controls

AOR1 (95% CI)

Cases/Controls

AOR1 (95% CI)

 

Cases/Controls

AOR1 (95% CI)

Cases/Controls

AOR1 (95% CI)

 

GG+AG

20/72

1.0

17/81

1.0

(0.4 – 2.5)

1.0

(0.4 – 2.5)

73/72

1.0

46/81

0.7

(0.4 – 1.4)

0.7

(0.4 – 1.4)

AA

18/20

6.9

(2.1 – 22.5)

3/21

0.6

(0.1 – 2.8)

0.09

(0.02 – 0.47)

41/20

2.9

(1.2 – 7.3)

20/21

0.9

(0.4 – 2.1)

0.3

(0.1 – 0.9)

AA vs. GG+AG

OR ratio

(95% CI)

 

6.9

(2.1 – 22.5)

 

0.6

(0.1 – 2.7)

  

2.9

(1.2 – 7.3)

 

1.2

(0.5 to 3.0)

 

p for interaction2

   

0.008

    

0.172

 
  1. 1 Odds ratios were adjusted for the covariates (age, gender, education level, pack-years of cigarette smoking and of betel quid chewing, and drink-years of alcohol drinking) listed in Table 1.
  2. 2Interaction was examined with likelihood ratio test for cross-product terms based on a multiplicative model.
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BMC Gastroenterology

ISSN: 1471-230X

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