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Table 3 Adjusted OR for cancers at upper, middle and lower third of the esophagus associated with COX-2 -1195G/A polymorphism.

From: Polymorphism in COX-2 modifies the inverse association between Helicobacter pyloriseropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study

COX-2 polymorphism

Controls

Location of ESCC

Total cases

  

Upper + Middle

Lower

  
 

No.

(%)

No.

(%).

AOR1

(95% CI)

No.

(%).

AOR1

(95% CI)

No.

(%).

AOR1

(95% CI)

GG

50

(26)

23

(19)

1.0

16

(28)

1.0

39

(22)

1.0

AG

103

(53)

59

(48)

1.7

(0.7 – 4.0)

21

(36)

0.9

(0.3 – 2.3)

80

(44)

1.2

(0.6 – 2.4)

AA

41

(21)

40

(33)

2.0

(0.7 – 5.2)

21

(36)

2.3

(0.8 – 6.7)

61

(34)

2.3

(1.0 – 5.2)

p for H-W2

0.471

      

GG+AG

153

(79)

82

(67)

1.0

37

(64)

1.0

119

(66)

1.0

AA

41

(21)

40

(33)

1.4

(0.7 – 2.9)

21

(36)

2.5

(1.0 – 6.1)

61

(34)

2.0

(1.1 – 3.9)

  1. 1 Odds ratios were adjusted for the covariates (age, gender, education level, pack-years of cigarette smoking and of betel quid chewing, and drink-years of alcohol drinking) listed in Table 1.
  2. 2 p value for Hardy-Weinberg equilibrium test.