Table 3 Demographic Data and Pharmacokinetic Parameter Estimates for Montelukast
Subject No. | Age (yr) | Dose (mg/kg) | Weight (kg) | Ka (1/hr) | Vd/F (L/kg) | Kel (1/hr) |
|---|---|---|---|---|---|---|
1 | 13 | 0.188 | 53.3 | 0.532 | 0.08 | 0.334 |
3 | 14 | 0.166 | 60.2 | 0.577 | 0.06 | 0.399 |
5 | 10 | 0.293 | 34.1 | 0.609 | 0.14 | 0.475 |
7 | 14 | 0.125 | 80.1 | 0.545 | 0.09 | 0.354 |
8 | 13 | 0.272 | 36.7 | 0.555 | 0.11 | 0.386 |
9 | 9 | 0.22 | 45.4 | 0.498 | 0.11 | 0.293 |
10 | 11 | 0.305 | 32.8 | 0.553 | 0.13 | 0.396 |
11 | 14 | 0.14 | 71.2 | 0.554 | 0.10 | 0.375 |
12 | 11 | 0.305 | 32.8 | 0.507 | 0.14 | 0.354 |
13 | 16 | 0.176 | 56.9 | 0.544 | 0.14 | 0.401 |
14 | 15 | 0.187 | 53.6 | 0.535 | 0.13 | 0.369 |
15 | 15 | 0.169 | 59.1 | 0.570 | 0.10 | 0.396 |
17 | 10 | 0.173 | 57.7 | 0.538 | 0.11 | 0.355 |
19 | 11 | 0.152 | 65.6 | 0.546 | 0.08 | 0.353 |
20 | 13 | 0.223 | 44.8 | 0.548 | 0.13 | 0.394 |
21 | 15 | 0.115 | 87.3 | 0.565 | 0.11 | 0.395 |
22 | 14 | 0.19 | 52.6 | 0.605 | 0.08 | 0.424 |
23 | 15 | 0.123 | 81.2 | 0.538 | 0.09 | 0.345 |
Mean (SD) | 12.9 (2.1) | 0.20 (0.06) | 55.9 (16.7) | 0.55 (0.03) | 0.11 (0.02) | 0.38 (0.04) |