Changes in PPARδ gene expression and Fra-2 activation over the period of CCl
administration (A) and CCl
withdrawal/recovery (B). Panel (C) shows the relationship between PPARδ and PON1 gene expressions in all the animals studied (treatment and recovery). Panels (D) shows representative micrographs of PPARδ protein expression in liver tissue of control rats (left) or animals treated with CCl4 for 12 weeks (right). Original magnification: ×100.