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Table 4 Association between SEPS1 polymorphism and tumor location, staging and Lauren's classification

From: Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population

Variables(n)

genotype

G/G vs. G/A+A/A

 
 

G/G

G/A

A/A

OR(95%CI)

P

Patients without GC(306)

283

22

1

Reference

 

Tumor location

     

   Cardia(5)

5

0

0

1.93(0.40–9.22)

0.411

   Non-cardia(263)

232

30

1

2.81(0.69–11.48)

0.15

   Upper third(16)

14

2

0

ND

 

   Middle third(134)

115

19

0

2.01(1.03–3.92)

0.041

   Lower third(113)

103

9

1

1.18(0.52–2.64)

0.696

Staging

     

   Early(138)

121

17

0

1.74(0.88–3.47)

0.112

   Advanced(130)

117

12

1

1.52(0.74–3.12)

0.253

Lauren's classification

     

   Intestinal type(151)

132

19

0

1.99(1.01–3.93)

0.047

   Diffuse type(110)

100

9

1

1.19(0.54–2.63)

0.659

   Mixed(7)

5

2

0

6.82(1.07–43.65)

0.043

  1. NOTE: All data are adjusted for sex, age, and H. pyloriinfection status. ND: not determined, GC: gastric cancer, CI: confident interval
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BMC Gastroenterology

ISSN: 1471-230X

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