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Table 5 Clinical characteristics of individuals with VA and inflammation – patient chart review.

From: Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers

  Villous atrophy;
N= 118
Inflammation;
N= 39
Background data   
Females 72 (61) 16 (41)
Median age at first biopsy; range (years) 42; 1–86 53; 1–84
Median follow-up; range (years) 7; 0–24 6; 0–17
Heredity   
Reported heredity for CD 14 (12) 2 (5)
Reported heredity for type 1 diabetes 3 (3) 0 (0)
Other diseases   
Diabetes Mellitus, type 1 5 (4) 1 (3)
Dermatitis herpetiformis 6 (5) 0 (0)
Other autoimmune disease 11 (9) 8 (21)
Symptoms   
Any gastrointestinal symptom* 93 (79) 25 (64)
Diarrhea 42 (36) 7 (18)
Anemia 41 (35) 12 (31)
Weight loss/growth failure 34 (29) 3 (8)
Abdominal pain 22 (19) 9 (23)
Vomiting or nausea 15 (13) 6 (15)
Constipation 12 (10) 1 (3)
Fatigue 9 (8) 3 (8)
Laboratory data   
Iron-deficiency 32 (27) 5 (13)
Folic acid deficiency 26 (22) 2 (5)
B12-deficiency 16 (14) 1 (3)
Thrombocytes, increased 15 (13) 4 (10)
Low albumin 12 (10) 7 (18)
Erythrocyte sedimentation rate, increased 9 (8) 3 (8)
Liver enzymes, increased 9 (8) 4 (10)
Biopsy report   
Original biopsy report could be examined through
patient chart reviews
98 (83) 33 (85)
Clinical data (about the patient) is described in the
biopsy referral letter (to the pathologist)#
90 (92) 28 (85)
Macroscopic appearance of the intestine is described
in the referral letter#
39 (40) 14 (42)
  1. Percentages are given within brackets. Although, the diagnosis CD was evaluated in 121 individuals, patient chart data were only available in 118 (98%).
  2. *Weight loss was included among "any GI symptom". Also reflux symptoms (not listed above) were included among "any GI symptoms".
  3. #Based on 98 and 33 biopsy reports respectively.